Pharmaceutical compositions comprising cyclosporins

Details Pharmaceutical compositions comprising cyclosporins Pharmaceutical compositions comprising cyclosporins

1992-12-15

1994-08-30

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424456, 424457, 424489, 514 11, 514885, 514937, 514938, 514963, 514964, 514970, 514974, 514975, 530321, A61K 966, A61K 9107, A61K 3702, C07K 764

Patent

active

053426258

ABSTRACT:
Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or [Nva].sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.

REFERENCES:
patent: 4108985 (1978-08-01), Ruegger et al.
patent: 4210581 (1980-07-01), Ruegger et al.
patent: 4220641 (1980-09-01), Traber et al.
patent: 4388307 (1983-06-01), Cavanak
patent: 4835002 (1989-05-01), Wolf et al.
patent: 4914188 (1990-04-01), Dumont et al.
patent: 4990337 (1991-02-01), Kurihara et al.
patent: 4996193 (1991-02-01), Hewitt et al.
W. A. Ritschel, et al., Pharm. Res., 1988 (May 1910), Suppl. 108.
Derwent No. 86/335072/51, (Apr. 26, 1985).
Takada, et al., J. Pharmacobia-Dyn., vol. 11, pp. 80-87 (1988).
Bryan D. Tarr, et al., Pharmaceutical Research, vol. 6, No. 1, pp. 40-43 (1989).
Reymond, et al., Pharmaceutical Research, vol. 5, No. 10, pp. 673-679 (1988).
Remington's Pharmaceutical Sciences, 17th Edition, pp. 298-299 (1985).
Derwent No. 87-086213/12 (1985).
Takada, et al., International Jour. of Pharmaceutics, vol. 44, pp. 107-116 (1988).
Derwent No. 89/088668/12 (Jul. 31, 1987).
Derwent 87/024776/04 (Apr. 4, 1985).
W. A. Ritschel, et al., Meth. Find. Exp. Clin. Pharmacol., vol. 11, pp. 281-285 (1989).

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