Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Patent
1993-09-17
1995-02-14
Lewis, Ralph A.
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
4351736, 604 51, A61N 130
Patent
active
053890698
ABSTRACT:
A method and apparatus is disclosed for causing electroporation of remote cells and tissue, in vivo. The method includes directing an electrically conductive penetrator into an organism to a point which is approximate to the cells and/or tissue. An electrode is disposed at a surface of the organism, whereby a voltage applied between the electrically conductive penetrator and the electrode will cause electroporation of the cells and/or tissue. A voltage is applied between the electrically conductive penetrator and the electrode in an amount sufficient to cause electroporation of the cell or tissue. The method can also include treating remote tissue, in vivo, with a chemical agent, wherein the chemical agent is disposed in the organism in an amount sufficient to treat the cell or tissue during electroporation.
REFERENCES:
patent: 578611 (1897-03-01), Rively
patent: 3078850 (1963-02-01), Schein et al.
patent: 3614955 (1971-10-01), Mirowski
patent: 3680544 (1972-08-01), Shinnick et al.
patent: 4055799 (1977-10-01), Coster et al.
patent: 4081340 (1978-03-01), Zimmerman et al.
patent: 4154668 (1979-05-01), Zimmerman et al.
patent: 4220916 (1980-09-01), Zimmerman et al.
patent: 4411648 (1983-10-01), Davis et al.
patent: 4578168 (1986-03-01), Hofmann
patent: 4663292 (1987-05-01), Wong et al.
patent: 4695547 (1987-09-01), Hilliard et al.
patent: 4764473 (1988-08-01), Matschke et al.
patent: 4784737 (1988-11-01), Ray et al.
patent: 4822470 (1989-04-01), Chang
patent: 4955378 (1990-09-01), Grasso
patent: 4979948 (1990-12-01), Geddes et al.
patent: 5007995 (1991-04-01), Takahashi et al.
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5047007 (1991-09-01), McNicols et al.
patent: 5098843 (1992-03-01), Calvin
Okino, et al., Journal of Japan Soc. for Cancer Therapy, 22(8):337 (1987).
Kanesada, et al., Journal of Japan Soc. for Cancer Therapy, 22(8):338 (1987).
Okino, et al., Japan Journal of Cancer Research, 46:420 (1987).
Mir et al., "Improvement of Anticancer Electrochemotherapy", Proceedings of the American Associate for Cancer Research, 30, p. 571 (1989).
Mir et al., "Pharmacological Applications of Electropermeabilization of Living Cells", Lab. de Biochimie-Enzymologie, Institute Gustave-Roussy 94805 Villejuif Cadex-France.
Mir et al., "Potentiation of Bleomycin by Local Electric Pulses: Experimental Anticancer Electrochemotherapy", Proceedings of the American Association for Cancer Research, 30, p. 440 (1990).
Mir et al., 'Electrochemotherapy Potentiation of Antitumour Effect of Bleomycin by Local Electric Pulses38 , Eur. F Cancer, 27(1):68-72 (1991).
Okino et al., "Effects of a High-Voltage Electrical Impulse and an Anticancer Drug on In Vivo Growing Tumors", Jpn. J. Cancer Res., 78(12):1319-1321 (1987).
Heroux et al., "Assessment of Trauma in Tissues By Electrical Impedance Measurements", Electromagnetics in Biology and Medicine, pp. 215-221 (1991).
Bhatt et al., "Rhabdomyolysis Due to Pulsed Electric Fields", Plastic and Reconstructive Surgery, 86(1):1-11 (1990).
Heller et al., "Transfer of Human Membrane Surface Components by Incorporating Human Cells into Intact Animal Tissue by Cell-Tissue Electrofusion In Vivo", Biochimica et Biophysica Acta., vol. 1024, pp. 185-188 (1990).
Titomirov et al., "In Vivo Electroporation and Stable Transformation of Skin Cells of Newborn Mice by Plasmid DNA", Biochimica et Biophysica Acta., vol. 1088, pp. 131-134 (1991).
Zimmerman et al, "Effects of External Electrical Fields on Cell Membranes", Bioelectrochemistry and Bioenergetics 3, 58-83 (1976).
Lewis Ralph A.
Massachusetts Institute of Technology
LandOfFree
Method and apparatus for in vivo electroporation of remote cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for in vivo electroporation of remote cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for in vivo electroporation of remote cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-284144