Retroviral vector having an ovalbumin promoter

Details Retroviral vector having an ovalbumin promoter Retroviral vector having an ovalbumin promoter

2008-05-27

2008-05-27

Wilson, Michael (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C435S325000

Reexamination Certificate

active

07378086

ABSTRACT:
Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to an embryonic chicken cell, so as to create a transgenic hen wherein the transgene is expressed in the hen's oviduct and the transgene product is secreted in the hen's eggs and/or those of her offspring. In a preferred embodiment, the transgene product is secreted in the egg white.

REFERENCES:
patent: 4650764 (1987-03-01), Temin et al.
patent: 5162215 (1992-11-01), Bosselman et al.
patent: 6825396 (2004-11-01), MacArthur
Bossleman (Science, Jan. 27, 1989, vol. 243, No. 4890, p. 533-535).
Vick (Proc. R. Soc. Lond., 1993, vol. 251, p. 179-182).
Love (Bio/Technology, 1994, vol. 12, p. 60-63).
Sang (TibTech, 1994, vol. 12, p. 415-420).
Thoroval (Transgenic Research, 1995, vol. 4, p. 369-376).
Mohammed (1998, Immunotechnology, vol. 4, p. 115-125).
Sayegh (Dec. 15, 1999, vol. 72, p. 31-37).
Harvey (Nature Biotech, Apr. 2002, vol. 19, p. 396-399).
Ivarie (Trends in Biotechnology, Jan. 2003, vol. 21, p. 14-19).
Chapman (Develop., 2005, vol. 132, p. 935-940).
Gao (J. Zhejiang Univ. SCI, 2005, vol. 6B (2): 137-141).
Wiese (Transgenic Res., 2006, vol. 15, p. 119).
Gaub (EMBO, 1987, vol. 6, No. 8, p. 2313-2320).
Proudman, 2001, “The quest for transgenic poultry: birds are not mice with feathers” Biotechnology in Animal Husbandry, vol. 5, Kluwer Academic Publishers, p. 283-299; p. 284, lines 1-6.
Mizuarai (Biochemical and Biophysical Res. Comm. Aug. 24, 2001, vol. 286, p. 456-463).
Jigami (1986, Gene, vol. 43, p. 273-279).
Dierich, EMBO Journal, 1987, vol. 6, No. 8,, p. 2305-2312.
Bosselman et al., Science, vol. 243, pp. 533-535, Jan. 27, 1989.
Bosselman, R.A., et al., “Germline Transmission Of Exogenous Genes in The Chicken,”Science243:533-535 (1989).
Bradshaw, M.S., et al., “Far Upstream Ovalbumin Enhancer Binds Nuclear Factor-1-like Factor,” J. Biol. Chem. 263(17):8485-8490 (1988).
Bradyopadhy, P.K., et al., “Expression of Complete Chicken Thymidine Kinase Gene Inserted In A Retrovirus Vector,” Mol. Cell Biol. 4(4):749-754 (1984).
Briskin, et al., “Heritable Retroviral Transgenes Are Highly Expressed in Chickens,” Proc. Natl. Acad. Sci. USA 88: 1736-1740, 1991.
Carscience, et al., “Germline Chimeric Chickens From Disperesed Donor Blastodermal Cells and Compromised Recipient Embryos,”Development117:669-675 (1993).
Corthesy, B., et al., “Estrogen-Dependent in Vitro Transcription from the Vitellogenin Promoter in Liver Nuclear Extracts,”Science239:1137-1139 (1998).
Crittenden, et al., “Transgenic Livestock Models in Medicine And Agriculture,” pp. 73-87 (Wiley-Liss (1990)).
Curran, T., et al., “Fos and Jun: The AP-1 Connection,”Cell55:395-397 (1988).
Davis, et al., Single Chain Antibody (SCA) Encoding Genes: One-Step Construction And Expression in Eukaryotic Cells,Biotechnol. 9:165-169 (1991).
Dierich, A., et al., “Cell-Specificity of The Chicken Ovalbumin And Conalbumin Promoters,”EMBO Journal6(8):2305-2312 (1987).
Dornburg, R., “Reticuloendotheliosis Viruses and Derived Vectors,” Gene Therapy 2: 301-310, 1995.
Dougherty, et al., “New Retrovirus Helper Cells With Almost No Nucleotide Sequence Homology to Retrovirus Vectors,” Journal of Virology, 63(7): 3209-3212, 1989.
Emerman, M., et al., “Genes With Promoters In Retrovirus Vectors Can Be Independently Suppressed By An Epigenetic Mechanism,”Cell39:459-467 (1984).
Emerman, M., et al., “High-Frequency Deletion In Recovered Retrovirus Vectors Containing Exogenous DNA With Promoters,”J. Virology50(1):42-49 (1984).
Etches, et al., “Chimeric Chickens And Their Use In Manipulation Of The Chicken Genome,”Poultry Science72:882-889 (1993).
Evans, M.I., et al., “A Somatomedin-Like Peptide Hormone Is Required During The Estrogen-Mediated Induction Of Ovalbumin Gene Transcription,”Cell25:187-193 (1981).
Evans, M.I., et al., “Regulation Of the Ovalbumin Gene: Effects of Insulin, Adenosine 3′, 5′-Monophosphate, And Estrogen,”Endocrinology115(1):368-377 (1984).
Gaub et al.,EMBO Journal, vol. 6, pp. 2313-2320, 1987.
Gaub, M.P., et al., “Activation of The Ovalbumin Gene By The Estrogen Receptor Involves The Fos-Jun Complex,”Cell63:1267-1276 (1990).
Harvey, J. et al., “Expression of Exogenous Protein in the Egg White of Transgenic Chickens,” Nature Biotechnology, Nature Publishing, vol. 19, Apr. 2002, pp. 396-399.
Harvey, J. et al., “Validating the Hen as a Bioreactor for the Production of Exogenous Proteins in Egg White,” Poultry Science, vol. 82, No. 6, Jun. 2003, pp. 927-930.
Helig, R., et al., “The Ovalbumin Gene Family—The 5′ End Region Of The X and Y Genes,”J. Mol. Biol. 156:1-19 (1982).
Houdebine, L.M., “Poduction of Pharmaceutical Proteins From Transgenic Animals,”J. Biotechnology34:269-287 (1984).
Jigami et al., Gene, vol. 43, pp. 273-279, 1986.
Jigami, Y., et al., “Expression Of Synthetic Human-Lysozyme Gene InSaccharomyces cerevisiae: Use Of A Synthetic Chicken—Lysozyme Signal Sequence For Secretion and Processing,”Gene43:273-279 (1986).
Jost et al., Nucleic Acid Methylation, vol. 128, pp. 313-328, 1990.
Kato, S., et al., “A Far Upstream Estrogen Response Element Of The Ovalbumin Gene Contains Several Hlaf—Palidromic 5′-TGACC-3′ Motifs Acting Synegistically,”Cell68:731-742 (1992).
Kaye, J.S., et al., “Steroid Hormone Dependence Of Four DNase I-Hypersensitive Regions Located Within The 700-bp 5′-Flanking Segment Of The Ovalbumin Gene,”EMBO J. 5(2):277-285 (1986).
Klein-Hitpass, L., et al., “Synergism Of Closely Adjacent Estrogen-Responsive Elements Increases Their Regulatory Potential,”J. Mol. Biol. 201:537-544 (1988).
Kozak, M., et al., “An Analysis of Vertebrate mRNA Sequence: Intimations Of Translational Control,” J. Cell Biol. 115(4):887-903 (1991).
Ktistaki, E., et al., “Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene,”Nuceleic Acids Research22(22):4689-4696 (1994).
Lemeur, M.A., et al., “Termination Of The Ovalbumin Gene Transcription,”EMBO Journal3(12):2779-2786 (1994).
Lilley, et al., “Recombinant Single-Chain Antibody Peptide Conjugates Expressed InEscherichia coliFor The Rapid Diagnosis Of HIV,”J. Immunol. Meth. 171:211-226 (1994).
Love, J., et al., “Transgenic Birds By DNA Microinjection,”Biotechnology12:60-63 (1994).
O'Hare, K., et al., “No More Than Seven Interruptions In The Ovalbumin Gene: Comparison Of Genomic And Double-Stranded cDNA Sequence,”Nucleic Acids Research7(2):321-334 (1979).
Olson et al., “Improved Self-Inactivating Retroviral Vectors Derived from Spleen Necrosis Virus,”Journal of Virology68(11): 7060-7066, 1994.
Petropolous, C.J., et al., “Using Avian Retroviral Vectors For Gene Transfer,”J. Virol. 66(6):3391-3397 (1992).
Petropoulos, C.J., et al., “Repliation-Competant Retrovirus Vectors For The Transfer And Expression Of Gene Cassettes In Avian Cells,”J. Virol. 65:3728-3737 (1991).
Ponglikitmongkol, M., et al., “Synergistic Activation Of Transcription By The Human Estrogen Receptor Bound To Tandem Responsive Elements,”EMBO Journal9(7):2221-2231 (1990).
Robinson, A., et al., “Isolation And Properties Of the Signal Region From Ovalbumin,”FEBS203(2):243-246 (1986).
Sagami, I., et al., “Identification Of Two Factors Required For Transcription Of The Ovalbumin Gene,”Mol. Cell. Biol. 6(12):4259-4267 (1986).
Sang, Trends Biotech., vol. 12, pp. 415-420, Oct. 1994.
Schweers

Affiliated with

Also associated with

Rating

Retroviral vector having an ovalbumin promoter does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Retroviral vector having an ovalbumin promoter, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Retroviral vector having an ovalbumin promoter will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2815536