Polymerase chain reaction using metallic glass-coated microwire

Details Polymerase chain reaction using metallic glass-coated microwire Polymerase chain reaction using metallic glass-coated microwire

2008-05-06

2008-05-06

Gray, Jill (Department: 1794)

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Rod, strand, filament or fiber

C428S375000, C428S389000, C174S1100AR, C148S110000, C427S171000, C427S120000

Reexamination Certificate

active

07368166

ABSTRACT:
A metallic glass-coated microwire has controllable surface porosity. The porosity is achieved by etching the metallic glass-coated microwire or other shapes of glass-coated bodies with acid after annealing to produce a multi-phase glass coating. Porous metallic glass-coated microwires are found to make superior PCR machines, which find use in a variety of in vivo, biochemical, and chemical sensors. Advantageously, the PCR apparatus is smaller, less expensive to construct than conventional units. It readily carries out in vivo passive or active operations.

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Saiki, R.K. et al., Primer-directed Enzymatic Amplification of DNA with Thermostable DNA Polymerase,Science 239(1988) pp. 487-491.

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