Human TSLP polynucleotides

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S252300, C435S254200, C435S410000, C435S320100, C530S350000

Reexamination Certificate

active

07405058

ABSTRACT:
The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.

REFERENCES:
patent: 5011912 (1991-04-01), Hopp et al.
patent: 2003/0099947 (2003-05-01), Bazan et al.
patent: WO 00/17362 (2000-03-01), None
patent: WO 00/39149 (2000-07-01), None
Candéias, S. et al., “Defective T-cell receptor γ gene rearrangement in interleukin-7 receptor knockout mice,”Immunol. Lett., 57:9-14, 1997.
Friend, S.L. et al., “A thymic stromal cell line supports in vitro development of surface IgM+E cells and produces a novel growth factor affecting B and T lineage cells,”Exp. Hematology 22(3):321-328, Mar. 1994.
Friend, S.L., and Far, A., “Initial characterization of Thymic Stromal Derived Lymphopoietin (TSLP),”FASEB J. 8: A506, 1994 (Abstract).
GenBank Accession No. AA889581, “EST;H. sapienscDNA clone Image: 1407260,” Apr. 6, 1998.
Lai, L. et al., Identification of an IL-7 associated pre-pro-B cell growth-stimulating factor (PPBSF) II. PPBSF is a covalently linked heterodimer of IL-7 and a Mr30,000 Co-factor1, J. Immunol. 160:2280-2286, Mar. 1, 1998.
Quentmeier, H. et al., “Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation,”Leukemia 15:1286-1292, 2001.
Ray, R.J. et al., “Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro,”Eur. J. Immunol. 26:10-16, Jan. 1996.

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