Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2008-03-18
2008-03-18
Anderson, Rebecca (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C562S015000
Reexamination Certificate
active
07345033
ABSTRACT:
The present invention provides a compound of the following formula I:in-line-formulae description="In-line Formulae" end="lead"?R3—NH—C(═X)—P(═O)OR1OR2in-line-formulae description="In-line Formulae" end="tail"?including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pharmaceutically acceptable salts, solvates, hydrates and polymorphs of said isomers and forms,whereinR1and R2may be the same or different and are each selected from hydrogen, acyloxyalkyl and aryl or R1and R2may form together with the oxygen and phosphorus atoms a dioxaphosphacycloalkane ring;X is O or S; andR3is selected, when X is O, from bicycloalkyl, cycloalkylalkyl and substituted cycloalkyl by at least one of alkyl, amino, amidino and guanidino; and R3is selected, when X is S, from bicycloalkyl, cycloalkylalkyl and cycloalkyl optionally substituted by at least one of alkyl, amino, amidino and guanidino; with the proviso that:when X is O, R3is not cyclohexylmethyl, andwhen X is S, R3is not cyclohexyl.The invention further provides pharmaceutical compositions comprising the above compounds and their use in medicine.
REFERENCES:
patent: WO 01/26661 (2001-04-01), None
patent: WO 01/26661 (2001-04-01), None
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Breuer Eli
Golomb Gershon
Katz Yiffat
Reich Reuven
Anderson Rebecca
Browdy and Neimark
Chu Yong
Yissum Research Development Company of the Hebrew University of
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