Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Reexamination Certificate
2008-05-27
2008-05-27
Gulakowski, Randy (Department: 1796)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
C525S054200, C525S056000, C528S094000
Reexamination Certificate
active
07378469
ABSTRACT:
The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an amine base and an organic solvent. The polymer backbone can be poly(ethylene glycol). The 1-benzotriazolylcarbonate ester can then be reacted directly with a biologically active agent to form a biologically active polymer conjugate or reacted with an amino acid, such as lysine, to form an amino acid derivative.
REFERENCES:
patent: 5629384 (1997-05-01), Veronese et al.
patent: 5650234 (1997-07-01), Dolence et al.
patent: 5985263 (1999-11-01), Lee et al.
patent: 6348558 (2002-02-01), Harris et al.
patent: 6376604 (2002-04-01), Kozlowski
patent: 6436386 (2002-08-01), Roberts et al.
patent: 6624246 (2003-09-01), Kozlowski
patent: 6710125 (2004-03-01), Kozlowski
patent: 287 951 (1992-03-01), None
Monfardini, et al. “A Branched Monomethyoxypoly(ethylene glycol) for Protein Modification”, J. Am. Chem. Soc., 1995, pp. 62-69, vol. 6, No. 1.
Shearwater Polymers, Inc. Catalog “Polyethylene Glycol Derivatives,” 1997-1998, 55 pages.
Shearwater Polymers, Inc. Catalog “Polyethylene Glycol Derivatives,” 2000, 52 pages.
Asinovsky Olga
Evans Susan T.
Gulakowski Randy
Nektar Therapeutics AL, Corporation
Wilson Mark A.
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