Systems and methods for detecting and analyzing polymers

Details Systems and methods for detecting and analyzing polymers Systems and methods for detecting and analyzing polymers

2008-07-22

2008-07-22

Whisenant, Ethan (Department: 1634)

Chemistry: molecular biology and microbiology

Apparatus

C435S006120, C435S007100

Reexamination Certificate

active

07402422

ABSTRACT:
A detection system and methods for improving the ability of the detection system to recognize labels that are disposed on a polymer. Embodiments of the invention include schemes for selecting emitters and labels used within the system in a manner that allows an increase in the number of distinct labels that can be used together in a system. In other embodiments, the detection system and methods are directed to identifying portions of a detection signal that may be associated with extra labels residing within a detection zone. In other embodiments, the detection system and methods relate to using wide field imaging detectors while reducing out of focus noise contributions to detection signals of the system. Still, other embodiments relate to the use of linear array detectors to detect labels.

REFERENCES:
patent: 4573796 (1986-03-01), Martin et al.
patent: 4833332 (1989-05-01), Robertson, Jr. et al.
patent: 5270214 (1993-12-01), Sessler et al.
patent: 5356776 (1994-10-01), Kambara et al.
patent: 5538613 (1996-07-01), Brumley et al.
patent: 5707797 (1998-01-01), Windle
patent: 5784157 (1998-07-01), Gorfinkel et al.
patent: 6038023 (2000-03-01), Carlson et al.
patent: 6139800 (2000-10-01), Chandler
patent: 6210896 (2001-04-01), Chan
patent: 6210973 (2001-04-01), Pettit
patent: 6245507 (2001-06-01), Bogdanov
patent: 6255083 (2001-07-01), Williams
patent: 6263286 (2001-07-01), Gilmanshin et al.
patent: 6306607 (2001-10-01), Williams
patent: 6355420 (2002-03-01), Chan
patent: 6403311 (2002-06-01), Chan
patent: 6635163 (2003-10-01), Han et al.
patent: 6696022 (2004-02-01), Chan et al.
patent: 6762059 (2004-07-01), Chan et al.
patent: 6772070 (2004-08-01), Gilmanshin et al.
patent: 6790671 (2004-09-01), Austin et al.
patent: 6927065 (2005-08-01), Chan et al.
patent: 7262859 (2007-08-01), Larson et al.
patent: 7282330 (2007-10-01), Zhao et al.
patent: 2002/0110818 (2002-08-01), Chan
patent: 2002/0119455 (2002-08-01), Chan
patent: 2002/0187508 (2002-12-01), Wong
patent: 2002/0197639 (2002-12-01), Shia et al.
patent: 2003/0058440 (2003-03-01), Scott et al.
patent: 2003/0059822 (2003-03-01), Chan et al.
patent: 2003/0215864 (2003-11-01), Gilmanshin et al.
patent: 2003/0235854 (2003-12-01), Chan
patent: 2004/0009612 (2004-01-01), Zhao et al.
patent: 2004/0053399 (2004-03-01), Gilmanshin
patent: 2004/0166025 (2004-08-01), Chan et al.
patent: 2004/0214211 (2004-10-01), Gilmanshin
patent: 2004/0235014 (2004-11-01), Nadel et al.
patent: 2005/0042665 (2005-02-01), Gilmanshin
patent: 2005/0112595 (2005-05-01), Zhao et al.
patent: 2005/0112606 (2005-05-01), Fuchs et al.
patent: 2005/0112620 (2005-05-01), Chan et al.
patent: 2005/0112671 (2005-05-01), Maletta et al.
patent: 2005/0123944 (2005-06-01), Neely et al.
patent: 2005/0123974 (2005-06-01), Gilmanshin et al.
patent: 2005/0142595 (2005-06-01), Maletta et al.
patent: 2005/0153354 (2005-07-01), Gilmanshin et al.
patent: 2005/0196790 (2005-09-01), Rooke et al.
patent: 2005/0221408 (2005-10-01), Nalefski et al.
patent: 2006/0078915 (2006-04-01), Fuchs et al.
patent: 2006/0134679 (2006-06-01), Larson et al.
patent: 2006/0160209 (2006-07-01), Larson et al.
patent: 2006/0160231 (2006-07-01), Nadel et al.
patent: 2006/0204978 (2006-09-01), Nilsen et al.
patent: 2006/0228747 (2006-10-01), Fuchs et al.
patent: 2006/0292616 (2006-12-01), Neely et al.
patent: 2006/0292617 (2006-12-01), Neely et al.
patent: 2007/0042406 (2007-02-01), Yantz et al.
patent: 2007/0128083 (2007-06-01), Yantz et al.
patent: 2007/0166743 (2007-07-01), Gilmanshin
patent: WO 98/10097 (1998-03-01), None
patent: WO 00/09757 (2000-02-01), None
patent: WO 2004/077692 (2004-09-01), None
[No Author Listed] “Discrete-Layer Notch and Rugate Notch Filters.” Barr Associates, Inc. Online. http://www.barrassociates.com/opticalfilters. php?type=rugate. 3 Pages. Printed Mar. 28, 2006.
Boone et al., Plastic advances microfluidic devices. Anal Chem. Feb. 1, 2002;74(3):78A-86A.
Castro et al., Single-Molecule Electrophoresis: applications to Biomolecular Detection. SPIE. 1995; 2396:79-85.
Dörre et al., Techniques for single molecule sequencing. Bioimaging. 1997;5:139-52.
Ekstrøm et al., Two-point fluorescence detection and automated fraction collection applied to constant denaturant capillary electrophoresis. Biotechniques. Sep. 2000;29(3):582-4, 586-9.
Nie et al., Probing individual molecules with confocal fluorescence microscopy. Science. Nov. 11, 1994; 266(5187):1018-21.
Radcliff et al., Basics of flow cytometry. Methods Mol Biol. 1998;91:1-24.
Shera et al., Detection of single fluorescent molecules. Chem Phys Letts. 1990; 174(6):553-7.
Shortreed et al., High-throughput single-molecule DNA screening based on electrophoresis. Anal Chem. Jul. 1, 2000; 72(13):2879-85.
Thomann et al., Automatic fluorescent tag detection in 3D with super-resolution: application to the analysis of chromosome movement. J Microsc. Oct. 2002; 208(Pt 1):49-64.
Cova et al., Evaluation and prospects for single-photon avalanche diodes and quenching circuits. J Mod Opt. Jun.-Jul. 2994;51(9-10):1267-88.

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