Chromogenic substances and use thereof for the determination...

Details Chromogenic substances and use thereof for the determination... Chromogenic substances and use thereof for the determination...

2008-07-29

2008-07-29

Powers, Fiona T (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Azo

C534S770000, C534S787000, C534S794000, C534S798000, C534S885000, C435S024000

Reexamination Certificate

active

07405280

ABSTRACT:
The invention relates to chromogenic compounds and the use thereof for the determination of enzymes of the family of carboxypeptidases N and carboxypeptidases U. The above is more specifically a compound of formula (I) in which A=(1), (2), (3), (4) or (5), R1, R2=H, —CH3, —CH(CH3)2, —OCH3, —Cl,—CF3,—OCF3,—SCH3, R3=an amino acid group which may be hydrolysed by a carboxypeptidase A and R4=a basic amino acid group.

REFERENCES:
patent: 4551272 (1985-11-01), Sugiyama et al.
patent: 6461832 (2002-10-01), Gilvarg
Mock and Xu, “Catalytic activity of carboxypeptidase B and of Carboxypeptidase Y with anisylazoformyl substrates,” Bioorganic & Medicinal Chemistry Letters, vol. 9, pp. 187-192. (1999)/.
Mock et al., “Arazoformyl peptide surrogates as spectrophotometric kinetic assay substrates for carboxypeptidase A,” Analytical Biochemistry, vol. 239, pp. 218-222 (1996).
Mock and Stanford, “Arazoformyl dipeptide substrates for thermolysin. Confirmation of a reverse protonation catalytic mechanism,” Biochemistry vol. 35 No. 23 pp. 7369-7377 (1996).
Schatteman et al., “Assay of procarboxypeptidase U, a novel determinant of the fibrinolytic cascade, in human plasma,” Clinical Chemistry vol. 45, No. 6 pp. 807-813 (1999).

Affiliated with

Also associated with

Rating

Chromogenic substances and use thereof for the determination... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chromogenic substances and use thereof for the determination..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chromogenic substances and use thereof for the determination... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2801450