Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reissue Patent
2008-04-15
2008-04-15
Marx, Irene (Department: 1651)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S546000, C514S721000, C514S734000, C514S371000, C514S885000, C514S934000, C514S551000
Reissue Patent
active
RE040246
ABSTRACT:
A method for suppressing undesired viral growth in a host which comprises administering to the host an effective amount of a compound of the formula:wherein R1, R2, R3and R4are independently selected from the group consisting of HO—, CH3O— and CH3(C═O) O—. The method is exemplified by inhibiting Tat transactivation of a lentivirus and in suppressing Herpes simplex virus.
REFERENCES:
patent: 4425327 (1984-01-01), Moeller et al.
patent: 4774229 (1988-09-01), Jordan
patent: 4880637 (1989-11-01), Jordan
patent: 5008294 (1991-04-01), Neiss et al.
patent: 5195965 (1993-03-01), Shantha
patent: 5276060 (1994-01-01), Neiss et al.
patent: 5342930 (1994-08-01), Orth et al.
patent: 5559149 (1996-09-01), Clum et al.
patent: 5663209 (1997-09-01), Huang et al.
patent: 5827898 (1998-10-01), Khandwala et al.
patent: 5837252 (1998-11-01), Sinnott et al.
patent: 5965616 (1999-10-01), Wang et al.
patent: 6071949 (2000-06-01), Mulshine et al.
patent: 6214874 (2001-04-01), Huang et al.
patent: 6245523 (2001-06-01), Altieri
patent: 6417234 (2002-07-01), Huang et al.
patent: 6777444 (2004-08-01), Huang et al.
Russell T. Jordan and Larry M. Allen, “Neoplasm Inhibitors Comprising Metal Salts and Phenol Derivatives,” Chemical Abstracts, vol. 111, No. 3, Jul. 17, 1989, p. 64.
Perry et al, Synthesis of Lignans, I. Nordihydroguaiaretic Acid 1, J. Org. Chem, 1972, vol. 37, No. 26, p. 4371-4376.
Giza et al., A self-inducing runaway-replication plasmid expression system utilizing the Ro protein, Elsevier Science Publishers B.V. (Biomedical Division), Gene 78, 1989, pp. 73-84.
Staal et al., Antioxidants Inhibits Stimulation of HIV Transcription, Aids Research and Human Retroviruses, 1993, vol. 9, No. 4, pp. 299-306.
Gnabre et al., Isolation of anti-HIV-1 lignans fromLarrea tridentateounter-current chromatography, Journal of Chromatography A., 719, 1996, pp. 353-364.
Gnabre et al., Characterization of Anti-HIV Lignans fromLarrea tridentateTetrahedrom, 1995, vol. 51, No. 45, pp. 12203-12210.
Weislow et al., New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Symthetic and Natural Products for AIDS—Antiviral Activity, Journal of the National Cancer Institute, 1989, vol. 81, No. 8, pp. 577-586.
Grabre et al., Inhibition of Human Immunodeficency Virus type 1 transcription and replication by DNA sequence-s-elective plant lignans, Proc. Natl. Acad. Sci. USA, 1995, vol. 92, pp. 11239-11243.
Gisvold et al., Ligans fromLarrea divaricata, Journal of Pharmecutical Sciences, 1974, vol. 63, No. 12, pp. 1905-1907.
Ru Chih C. Huang et al., “Regulation of HIV Promoter Activities in Human Embryonal Carcinoma Cells, Ntera-2”, Gene Regulation and Aids, T. S. Papas, ed. 1989, pp. 147-160.
Paul E. Giza and Ru Chih C. Huang, “A Self-Inducing Runaway-Replication Plasmid Expression System Utilizing the RPO Protein,”Gene, 78(1989) pp. 73-84.
Chemical Abstracts No. 101816r, vol. 110, No. 11, issued Mar. 13, 1989, Jordan, “Compositions Containing Catecholic Butanes and Zinc For Treating Solid Tumors”.
Chemical Abstracts No. 118499d vol. 118499d vol. 112, No. 13, issued Mar. 26, 1990, Rao, “Regioselective Cleavage of the Methylendioxy Group: Conversion of(-)-Austrobailignan-5 To (-)-Dihydroguairetic Acid.”
Gnabre John N.
Huang Ru Chih C.
Hobbs Ann S.
John Hopkins University
Marx Irene
Venable LLP
LandOfFree
Method for the suppression of viral growth does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the suppression of viral growth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the suppression of viral growth will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2799647