Stabilized albumin preparations

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

active

07351800

ABSTRACT:
This invention provides albumin preparations with safety and without any risk of side effects, which are free from viruses or contaminating proteins and can be stably stored over a long time while showing neither changes in appearance nor decrease in content.There are provided a stabilized albumin preparation produced by uniformly mixing a medium-chain fatty acid or a salt thereof and a sulfur-containing amino acid or a derivative thereof with an aqueous albumin solution (e.g., a buffer such as phosphate buffer which can be administered as pharmaceutical preparations, injection water, or a physiological saline) and dissolving them therein, and then processing the mixture solution into a formulation suitable for parenteral administration such as an intravenous fluid preparation or an injectable solution, and a stabilization method for an albumin preparation.

REFERENCES:
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Ballou, Gerald et al., “The Heat Coagulation of Human Serum Albumin,”J. Biol. Chem., 153, 1944, pp. 589-605.
Boyer, Paul D. et al., “The Combination of Fatty Acids and Related Compounds with Serum Albumin,”J. Biol. Chem., 162, 1946, pp. 181-198.
Scatchard, G. et al., “Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. XXVI. the Properties of Solutions of Human Serum Albumin of Low Salt Content,”J. Clin. Invest., 24, 1945, pp. 671-679.
“Recombinant Albumin as a Pharmaceutical,”Clinical Molecular Medicine, 1, 1993, pp. 939-943.

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