Solid-phase peptide synthesis and agent for use in such...

Details Solid-phase peptide synthesis and agent for use in such... Solid-phase peptide synthesis and agent for use in such...

2008-03-25

2008-03-25

Tsang, Cecilia J. (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

C514S002600

Reexamination Certificate

active

07348404

ABSTRACT:
The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents which are useful in solid-phase peptide synthesis.

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patent: 7176282 (2007-02-01), Holm et al.
patent: 2006/0063699 (2006-03-01), Larsen
Cameron et al., “Feedback Control in Organic Synthesis. A System for Solid Phase Peptide Synthesis with True Automation,”J. Chem. Soc., Chem. Commun. 4:270-272 (1987).
Chou et al., “Empirical Predictions of Protein Conformation,”Ann. Rev. Biochem. 47:251-276 (1978).
Kent, “Chemical Synthesis of Peptides and Proteins,”Ann. Rev. Biochem. 57:957-989 (1988).
Larsen et al., “Incomplete Fmoc Deprotection in Solid-phase Synthesis of Peptides,”Int. J. Peptide Protein Res. 43:1-9 (1994).
Larsen et al., “The Merrifield Peptide Synthesis Studied by Near-Infrared Fourier-Transform Raman Spectroscopy,”J. Am. Chem. Soc. 115:6247-6253 (1993).
Meidal et al., “Multiple column peptide synthesis, Part 2 (1,2),”Int. J. Peptide Protein Res. 41:250-260 (1993).
Merrifield, “Solid Phase Synthesis,”Science232:341-347 (1986).
Rapp et al., “Prediction and Prevention of Peptide Conformations during Synthesis,” inPeptides: Chemistry, Structure and Biology, pp. 40-43 (1994).

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