5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and thei

Details 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and thei 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and thei

1980-03-28

1981-10-27

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424856, 546257, 546258, 544 82, 544124, C07D40104, A61K 3144, C07D41314, A61K 31535

Patent

active

042973600

ABSTRACT:
2-R.sub.3 RN-3-R.sub.1 R'N-5-PY-6-Q-pyridines (I) or pharmaceutically-acceptable acid-addition salts thereof are useful as intermediates in the preparation of 1- or 3-substituted-1,3-dihydro-5-Q-6-PY-2H-imidazo[4,5-b]pyridin-2-ones or -2-thiones and also as intermediates for preparing 1- or 3-substituted-5-Q-6-PY-3H(or 1H)-imidazo[4,5-b]pyridines, where R.sub.1, R.sub.3, R, R', PY and Q are defined hereinbelow. Also shown are processes for preparing I and the following intermediates used therein: 2-halo-3-nitro-5-PY-6-Q-pyridines (III), 2-R.sub.3 RN-3-nitro-5-PY-6-Q-pyridines (V), 2-halo-5-PY-6-Q-pyridines (VII), 2-R.sub.3 RN-5-PY-6-Q-pyridines (VIII) and 2-R.sub.3 RN-3-halo-5-PY-6-Q-pyridines (IX) or salts thereof. Certain embodiments of II and VIII also are useful as cardiotonics and are shown as active components of cardiac compositions and methods for increasing cardiac contractility.

REFERENCES:
patent: 3838156 (1974-09-01), Brundage et al.
patent: 4072746 (1978-02-01), Lesher et al.
patent: 4107315 (1978-08-01), Lesher et al.
patent: 4137233 (1979-01-01), Lesher et al.
patent: 4225715 (1980-09-01), Lesher et al.
Baldwin et al., Jour. of Medicinal Chemistry, vol. 20, pp. 1189-1193 (1977).

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