Methods for detection of mycobacteria

Details Methods for detection of mycobacteria Methods for detection of mycobacteria

2008-04-08

2008-04-08

Zara, Jane (Department: 1635)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C435S006120, C435S007200, C530S300000, C530S350000, C530S387900

Reexamination Certificate

active

07355016

ABSTRACT:
Nucleic acid encoding four novel immunodeterminant protein antigens ofM. bovisBCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library ofM. bovisBCG DNA and screened with sera collected from tuberculosis patients. The BCG DNA expressed an antigen of Mr 90 kD, and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was indentified to encode a membrane bound, ion-motive ATPase ofM. bovisBCG. The approach described here can be used to identify immunogens of mycobacteria. The well-characterizedM. bovisBCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis. The 79 kD antigen is also useful in the design of recombinant vaccines against different pathogens. The sequence of the 79 kD membrane-associated polypeptides also are useful for the development of specific PCR amplification based diagnostic procedures for the detection of mycobacteria. The promoter of the 79 kD antigen is useful for expressing homologous and/or heterologous antigens in mycobacteria.

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