Intravascular delivery of nucleic acid

Details Intravascular delivery of nucleic acid Intravascular delivery of nucleic acid

2008-07-08

2008-07-08

Wilson, Michael C. (Department: 1632)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S320100, C424S093200

Reexamination Certificate

active

07396821

ABSTRACT:
Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian blood vessel. Prior to insertion, subsequent to insertion, or concurrent with insertion the permability of the vessel is increased using an exterior cuff and immunosuppression is applied thereby the genetic material is delivered to the parenchymal cell.

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