Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2008-07-08
2008-07-08
Li, Q. Janice (Department: 1633)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C424S093100, C424S093200, C514S04400A, C435S320100
Reexamination Certificate
active
07396528
ABSTRACT:
The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and allo-transplantation utilising the modified corneal tissue. The method of modifying cells of corneal tissue to express an active agent involves exposing harvested corneal tissue to an effective concentration for transfection of an expression vector which comprises a nucleotide sequence encoding for the active agent for a period sufficient to allow infection, such that cells of the corneal tissue will express the active agent.
REFERENCES:
patent: 5770580 (1998-06-01), Ledley et al.
patent: 6338851 (2002-01-01), Gorczynski
patent: WO 96/13276 (1996-05-01), None
Peterson, Statement of Amy Patterson M.D., Feb. 2000.
Orkin et al. NIH Report, Dec. 1995.
Arancibia-Carcamo, C. V., et al., “Lipoadenofection-Mediated Gene Delivery to the Corneal Endothelium,”Transplantation, 65(1):62-67 (1998).
Bloom, David C., et al., “Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus,”Molecular Brain Research31:48-60 (1995).
Boehler, A., et al., “Adenovirus-Mediated Interleukin-10 Gene Transfer Inhibits Post-Transplant Fibrous Airway Obliteration in an Animal Model of Bronchiolitis Obliterans,”Human Gene Therapy, 9:541-551 (1998).
Borras, T., et al., “Ocular Adenovirus Gene Transfer Varies in Efficiency and Inflammatory Response,”Investigative Ophthalmology&Visual Science, 37(7):1282-1293 (1996).
Brauner,MD., R., et al., “Intracoronary Adenovirus-Mediated Transfer of Immunosuppressive Cytokine Genes Prolongs Allograft Survival,”J. Thoracic and Cardio. Surg., 114(6):923-933 (1997).
Budenz, Donald L., et al., “In Vivo Gene Transfer Into Murine Corneal Endothelial and Trabecular Meshwork Cells,”Investigative Ophthalmology&Visual Science, 36(11):2211-2215 (1995).
Byrnes, A.P., et al., “Adenovirus Gene Transfer Causes Inflammation in the Brain,”Neuroscience66(4):1015-1024 (1995).
DeBruyne, LA., et al., “Lipid-mediated gene transfer of viral IL-10 prolongs vascularized cardiac allograft survival by inhibiting donor-specific cellular and humoral immune responses,”Gene Therapy, 5:1079-1087 (1998).
Fehervari, Z., et al., “Gene Transfer to Ex Vivo Stored Corneas,”Cornea, 16(4):459-464 (1997).
Gogolin-Ewens, K.J., et al., “Sheep lymphocyte antigens (OLA),”Immunology, 56:717-723 (1985).
Goldman, Mitchell J., et al., “Transfer of the CFTR Gene to the Lung of Nonhuman Primates with E1-Deleted, E2a-Defective Recombinant Adenoviruses: A Preclinical Toxicology Study,”Human Gene Therapy, 6:839-851 (1995).
Graham, F.L., et al., “Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5,”J. Gen. Virol., 36:59-72 (1977).
Graham, Frank L. and Prevec, Ludvik, “Manipulation of Adenovirus Vectors,”Methods in Molecular Biol., 7:109-128 (1991).
Griffith, Thomas S. and Ferguson, Thomas A., “The role of FasL-induced apoptosis in immune privilege,”Immunology Today, 18(5): (1997).
Grooby, W.L., et al., “Use of an Anti-LFA-1 Antibody in Renal Allograft Rejection in Sheep,”Transplantation Proceedings, 24(5):2304 (1992).
Hoffman, Lisa M., et al., “Cell-Mediated Immune Response and Stability of Intraocular Transgene Expression After Adenovirus-Mediated Delivery,”Investigative Ophthalmology&Visual Science, 38(11):2224-2233 (1997).
Holland, Edward J., et al., “Clinical and Immunohistologic Studies of Corneal Rejection in the Rat Penetrating Keratoplasty Model,”Cornea10(5):374-380 (1991).
Hudde, T., et al., “Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium,”Gene Therapy, 6:939-943 (1999).
Kanegae, Y., et al., “A Simple and Efficient Method for Purification of Infectious Recombinant Adenovirus,”Jnp. J. Med. Sci. Biol., 47:157-166 (1994).
Larkin, D.F.P., et al., “Adenovirus-Mediated Gene Delivery To The Corneal Endothelium,”Transplantation61(3):363-370 (1996).
Mackay, C.R., et al., “Characterization of two sheep lymphocyte differentiation antigens SBU-T1 and SBU-T6,”Immunology55:729-737 (1985).
Mackay, Charles Reay, et al., “Three Distinct Subpopulations of Sheep T Lymphocytes,”Eur. J. Immunol. 16:19-25 (1986).
Maddox, J.F., et al., “Surface Antigens, SBU-14 and SBU-T8, of Sheep T Lymphocyte Subsets Defined by Monoclonal Antibodies,”Immunology55:739-748 (1985).
Maddox, J.F., et al., “The Sheep Analogue of Leucocyte Common Antigen (LCA),”Immunology55:347-353 (1985).
Malefyt, R. deWaal, et al., “Interleukin-10,”Curr. Opinion in Immunology4:314-320 (1992).
Martin H.M., et al., “Cloning and characterisation of an ovine interleukin-10-encoding cDNA,”Gene159:187-191 (1995).
Moore, KW., et al., “Interleukin-10,” Annual ReviewsImmunol. 11:165-90 (1993).
Oral, HB., et al., “Ex vivo adenovirus-mediated gene transfer and immunomodulatory protein production in human cornea,”Gene Therapy4:639-647 (1997).
Palmer, Theo D., et al., “Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes,”Proc. Natl. Acad. Sci. USA88:1330-1334 (1991).
Pepose, Jay S., et al., “Detection of HLA Class I and II Antigens in Rejected Human Corneal Allografts,”Ophthalmology92(11):1480-1484 (1985).
Philipson, Lennart, et al., “Virus-Receptor Interaction in an Adenovirus System,”J. Virology2:1064-1075 (1968).
Pleyer, U., et al., “Liposome-mediated gene transfer into corneal endothelial cells,”Invest. Ophthalmol. Vis. Sci., 38: S402 (1997).
Puri, N.K., et al., “Sheep lymphocyte antigens (OLA),”Immunology56:725-733 (1985).
Qian, Shiguang, et al., “Systemic Administration of Cellular Interleukin-10 Can Exacerbate Cardiac Allograft Rejection in Mice,”Transplantation62(12):1709-1714 (1996).
Qin, L., et al., “Retrovirus-Mediated Transfer of Viral IL-10 Gene Prolongs Murine Cardiac Allograft Survival,”J. Immunology,pp. 2316-2323 (1996).
Qin, Lihui, et al., “Adenovirus-Mediated Gene Transfer of Viral Interleukin-10 Inhibits the Immune Response to Both Alloantigen and Adenoviral Antigen,”Human Gene Therapy8:1365-1374 (1997).
Raisanen-Sokolowki, Anne, et al., Heart Transplants in Interferon-γ, Interleukin 4, and Interleukin 10 Knockout Mice,J. Clin. Invest. 100(10):2449-2456 (1997).
Raisanen-Sokolowki, Anne, et al., “Leukocyte-Suppressing Influences of Interleukin (IL)-10 in Cardiac Allografts,”Am. J. Pathology153(5):1491-1500 (1998).
Sano, Yoichiro, et al., “Cytokine Expression during Orthotopic Corneal Allograft Rejection in Mice,”IVOS39(10):1953-1957 (1998).
Seth, Prem, et al., “Evidence that the Penton Base of Adenovirus Is Involved in Potentiation of Toxicity ofPseudomonasExotoxin Conjugated to Epidermal Growth Factor,”Molecular and Cellular Biology4(8):1528-1533 (1984).
Sherrard, Emil S., “The Corneal Endothelium in vivo: its Response to Mild Trauma,”Exp. Eye Res. 22:347-357 (1976).
Shinozaki, K., et al. “Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation,”Gene Therapy6:816-822 (1999).
Simonsen, A. Hjorth, “Thymidine Incorporation by Human Corneal Endothelium During Organ Culture,”ACTA Ophthalmologica59:110-118 (1981).
Torres, Paulo F., et al. “Interleukin 10 Treatment Does Not Prolong Experimental Corneal Allograft Survival,”Ophthalmic Res. 31:297-303 (1999).
Treffers, MD., W. Frits, “Human Corneal Endothelial Wound Repair,”Ophthalmology89:605-613 (1982).
Tuft, Stephen J., “Endothelial Repair in the Rat Cornea,”Invest. Ophthalmol Vis. Sc
Coster Douglas John
Klebe Sonja
Williams Keryn Anne
Hamilton Brook Smith & Reynolds P.C.
Li Q. Janice
LandOfFree
Corneal cells expressing active agents and methods of use... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Corneal cells expressing active agents and methods of use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Corneal cells expressing active agents and methods of use... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2779118