Genetic variation in pro-melanin-concentrating hormone gene...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S091200

Reexamination Certificate

active

08008011

ABSTRACT:
An A-to-T single nucleotide polymorphism (SNP) identified at position −134 relative to the ATG start codon, in the Pro-Melanin-Concentrating Hormone (PMCH) gene ofBos taurusandBos indicusanimals of both British and Continental type, is associated with changes in the average fat and grade fat. The A allele occurred in 67% of cattle examined and was associated with higher average fat and grade fat levels. The cattle industry may make use of these findings to genetically select for, and/or sort, cattle using this SNP.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
Wall et al (2003) Nature Reviews. vol. 4, pp. 587-597.
Mummidi et al (2000) Journal of Biological Chemistry, vol. 275, No. 25, pp. 18946-18961.
Juppner (1995) Bone vol. 17, No. 2, Supplement, Aug. 1995:39S-42S.
Hacker et al (1997) Gut 1997; 40:623-627.
Lucentini (2004) The Scientist. Dec. 20, 2004, p. 20.
Hegele. Arterioscler Thromb Vasc Biol. 2002; 22:1058-1061.
Helgeson and Schmutz (GenBank Record having Accession DQ499531.1; GI: 98978958, Apr. 30, 2007).
Baker, B.I. (1994) Melanin-concentrating hormone updated: Functional considerations, Trends in Endocrinology and Metabolism 5, 120-126.
Barth, A.D., Cates, W.F., & Harland, R.J. (1995) The effect of amount of body fat and loss of fat on breeding soundness classification of beef bulls. Canadian Veterinary Journal 36, 758-764.
Buchanan, F.C., Fitzsimmons, C.J., Van Kessel, A.G., Thue, T.D., Winkelman-Sim, D.C., & Schmutz, S.M. (2002) Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels. Genetics Selection Evolution 34, 105-116.
Casas, E., Stone, R.T., Keele, J.W., Shackelford, S.D., Kappes, S.M., & Koohmaraie, M. (2000) Quantitative trait loci affecting growth and carcass composition of cattle segregating alternative forms of myostatin. Journal of Animal Science 78, 560-569.
Cowell, E.G., Skinner, A., & Hurst, H.C. (1992) Transcriptional Repression by a novel member of the bZIP family of transcription factors. Molecular and Cellular Biology 12, 3070-3077.
Cowell, I.G. (2002) E4BP4/NFIL3, a PAR-related bZIP factor with many roles. BioEssays 24, 1023-1029.
Gavrila, A., Chan, J.L., Miller, L.C., Heist, K., Yiannakouris, N., & Mantzoros, C.S. (2005) Circulating {grave over (m)}elanin-concentrating hormone, agouti-related protein, and α-melanin-stimulating hormone levels in relation to body composition: Alterations in response to food deprivation and recombinant human leptin administration. The Journal of Clinical Endocrinology and Metabolism 90, 1047-1054.
Ge W., Davis, M.E., Hines H.C., Irvin K.M. & Simmen R.C.M. (2001) Association of a genetic marker with blood serum insulin-like growth factor-I concentration and growth traits in Angus cattle. Journal of Animal Science 79, 1757-62.
Gregory, K.E., Cundiff, L.V., Koch, R.M., Dikeman, M.E., & Koohmaraie, M. (1994) Breed effects and retained heterosis for growth, carcass, and meat traits in advanced generations of composite populations of beef cattle. Journal of Animal Science 72, 833-850.
Helgeson, S.C. (2008) Genetic Variation in Pro-Melanin Concentrating Hormone Affects Carcass Traits in Bos Taurus Cattle. MSC Thesis, University of Saskatchewan.
Ito, M., Gomori, A., Ishihara, A., Oda, Z., Mashiko, S., Matsushita, H., Yumoto, M., Ito, M., Sano, H., Tokita, S., Moriya, M., Iwaasa, H., & Kanatani, A., (2003) Characterization of MCH-mediated obesity in mice. American Journal of Physiology, Endocrinology, and Metabolism 284, E940-E945.
Kapfhamer, D. & Burmeister, M. (1994) Genetic map of the region around grizzled (gr) and mocha (mh) on mouse chromosome 10, homologous to human 19p13.3. Genomics 23, 635-642.
Kappes S.M., Keele J.W., Stone R.T., McGraw R.A., Sonstegard T.S., Smith T.P.L., Lopez-Corrales N. L. & Beattie C.W. (1997) A second-generation linkage map of the bovine genome. Genome Research 7, 235-49.
Lai C.K. & Ting L.P. (1999) Transcriptional repression of human hepatitis B virus genes by a bZIP family member, E4BP4. Journal of Virology 73, 3197-209.
Li, C., Basarab, J., Snelling, W.M., Benkel, B., Kneeland, J., Murdoch, B., Hansen, C., & Moore, S.S. (2004) Identification and fine mapping of quantitative trait loci for backfat on bovine chromosomes 2, 5, 6, 19, 21, and 23 in a commercial line of Bos taurus. Journal of Animal Science 82, 967-972.
Ludwig, D.S., Tritos, N.A., Mastaitis, J.W., Kulkarni, R., Kokkotou, E., Elmquist, J., Lowell, B., Flier, J.S., & Maratos-Flier E. (2001) Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. The Journal of Clinical Investigation 107, 379-386.
Matys V., Fricke E., Geffers R. et al. (2003) TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Research 31, 374-378.
Mitsui, S., Yamaguchi, S., Matsuo, T., Ishida, Y., & Okamura, H. (2001) Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism. Genes and Development 15, 995-1006.
Pedeutour F., Szpirer C. & Nahon J.-L. (1994) Assignment of the human pro-melanin-concentrating hormone gene (PMCH) to chromosome 12q23-q24 and two variant genes (PMCHL1 and PMCHL2) to Chromosome 5p14 and 5q12-q13. Genomics 19, 31-7.
Pissios, P., Bradley, R.L., & Maratos-Flier, E. (2006) Expanding the scales: The multiple roles of MCH in regulating energy balance and other biological functions. Endocrine Reviews 27, 606-620.
Pugh K. (2008) An evaluation of the corticotrophin-releasing hormone and leptin gene SNPs relative to cattle behaviour. MSc Thesis, University of Saskatchewan.
Schenkel, F.S., Miller, S.P., Ye, X., Moore, S.S., Nkrumah, J.D., Li, C., Yu, J., Mandell, I.B., Wilton, J.W., & Williams, J.L. (2005) Association of single nucleotide polymorphisms in the leptin gene with carcass and meat quality traits of beef cattle. Journal of Animal Science 83, 2009-2020.
Schmutz, S.M., Marquess, F.L., Berryere, T.G., & Moker, J.S. (1995) DNA marker-assisted selection of the polled condition in charolais cattle. Mammalian Genome 6, 710-713.
Schmutz, S.M., Buchanan, F.C., Winkelman-Sim, D.C., Pawlyshyn, V., Plante, Y., McKinnon, J.J., & Fournier, B.P. (2001) Development of the Canadian beef reference herd for gene mapping studies. Theriogenology 55, 963-972.
Shimada, M., Tritos, N.A., Lowell, B., Flier, J.S., & Maratos-Flier, E. (1998) Mice lacking melanin-concentrating hormone are hypophagic and lean Nature 396, 670-674.
Skinner, J.D. (1981) Nutrition and fertility in pedigree bulls. In: Environmental factors in mammal reproduction (ed. by D. Gilmore & B. Cook), pp. 160-168. Macmillan, London.
Stone, R.T., Grosse, W.M., Casas, E., Smith, T.P.L., Kelle, J.W., and Bennett, G.L. (2002) Use of bovine EST data and human genomic sequences to map 100 gene-specific bovine markers. Mammalian Genome 13, 211-215.
Viale, A., Zhixing, Y., Breton, C., Pedeutour, F., Coquerel, A., Jordan, D., & Nahon, J-L. (1997) The melanin-concentrating hormone gene in human: Flanking region analysis, fine chromosome mapping, and tissue-specific expression. Molecular Brain Research 46, 243-255.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Genetic variation in pro-melanin-concentrating hormone gene... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Genetic variation in pro-melanin-concentrating hormone gene..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Genetic variation in pro-melanin-concentrating hormone gene... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2778960

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.