Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-03-15
2011-03-15
Harris, Alana M (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S007100, C435S007210, C436S063000, C436S064000, C436S174000
Reexamination Certificate
active
07906294
ABSTRACT:
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival and select treatment modalities for breast cancer. The present invention is also a method for inducing apoptosis in breast cancer cells by inhibiting the expression or activity of Spot 14. Compositions and methods for treating breast cancer are also provided.
REFERENCES:
patent: 2005/0112118 (2005-05-01), Cimbora et al.
Cunningham et al. “Spot 14” protein: a metabolic integrator in normal and neoplastic cells. Thyroid 8(9): 815-825, Sep. 1998.
Campbell et al., “Human Spot 14 Glucose and Thyroid Hormone Response: Characterization and Thyroid Hormone Response Element Identification”, Endocrinology 2003 144(12):5242-5248.
Cunningham et al., ““Spot 14” protein: a metabolic integrator in normal and neoplastic cells”, Thyroid 1998 8(9):815-825, Abstract only.
Heemers et al., “Progestins and Androgens Increase Expression of Spot 14 in T47-D Breast Tumor Cells”, Biochemical and Biophysical Research Communications 2000 269:209-212.
Joyeux et al., “Progestin Increases Gene Transcription and Messenger Ribonucleic Acid Stability of Fatty Acid Synthetase in Breast Cancer”, Molecular Endocrinology 1989 4:681-686.
Kinlaw et al., “Minireview: Spot 14: A Marker of Aggressive Breast Cancer and Potential Therapeutic Target”, Endocrinology 2006 147:4048-4055.
Lieberman et al., “The Constitution of a Progesterone Response Element”, Molecular Endocrinology 1993 7:515-527.
Moncur et al., “The “Spot 14” gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: Implications for control of tumor metabolism”, Proc. Natl. Acad. Sci. USA 1998 95:6989-6994.
Sanchez-Rodriguez et al., “The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells”, Biochem. J. 2005 390:57-65.
Wells et al., “Expression of “Spot 14” (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker”, Breast Cancer Research and Treatment 2006 98:231-240.
Harris Alana M
Licata & Tyrrell P.C.
Trustees of Dartmouth College
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