Polypeptides with morphine-like activity

Details Polypeptides with morphine-like activity Polypeptides with morphine-like activity

1977-03-14

1978-07-04

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

040987817

ABSTRACT:
The polypeptides R-Tyr-Gly-Gly-Phe-Met-Thr-Ser-OH in which R is hydrogen or arginyl, or a non-toxic salt thereof, exert an analgesic effect in rats when injected into the lateral brain ventricle.

REFERENCES:
patent: 4038222 (1977-07-01), Li
G. Ungar, et al., Opiates and Endogenous Opioid Peptides, 1976, pp. 121-128.
D. H. Coy, et al., Biochem. and Biophys. Res. Commun., 73, 1976, pp. 632-638.

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