Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-05-13
2008-05-13
Crane, L. E. (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S025330, C536S026220, C536S026230, C536S026260, C536S026700, C536S026800, C436S501000, C436S518000
Reexamination Certificate
active
07371852
ABSTRACT:
Alkyl-linked nucleotide non-homogeneous solid supports and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in the invention are methods for synthesis of an alkyl-linked nucleotide, nucleotide affinity media and methods of use thereof for affinity chromatography and screening methods.
REFERENCES:
patent: 4529796 (1985-07-01), Kang et al.
patent: 4988680 (1991-01-01), Halazy et al.
patent: 5536822 (1996-07-01), Haystead
patent: 5650510 (1997-07-01), Webb, II et al.
patent: 5780617 (1998-07-01), Van den Bosch et al.
patent: 5854228 (1998-12-01), Webb, II et al.
patent: 5976492 (1999-11-01), Griffiths et al.
patent: 5981507 (1999-11-01), Josephson et al.
patent: 2004/0241649 (2004-12-01), Huang
patent: 0269947 (1988-06-01), None
patent: 0338887 (1999-10-01), None
patent: WO00/63694 (2000-10-01), None
Trayer et al., “Preparation of Adenosine Nucleotide Derivatives Suitable for Affinity Chromatography,” Biochemical Journal, 139, 609-623 (1974).
Peters et al., “Chemical Crosslinking: Reagents and Problems in Studies of Membrane Structure,” Annual Reviews in Biochemistry, 46, 523-551 (1977).
Van Aeroschot et al., “Silica Gel Functionalised with Different Spacers as Solid Support for Oligonucleotide Synthesis,” Nucleosides & Nucleotides, 7(1), 75-90 (1988).
Google of “proteome,” See <http//en.wikipedia.org/wiki/Proteome>, accessed on Sep. 20, 2006.
Shibaev et al., “New Affinity-Chromatography Adsorbents Derived From Uridine Nucleotide Phosphoryl Amides,” Bioorganicheskaya Khimiya, 3(1), 120-126 (1977): Chemical Abstracts, 86, 1216783 (1977); only Abstract supplied.
Shibaev et al., “New Affinity-Chromatography Adsorbants Derived From Uridine Nucleotide Phosphoryl Amides,” Bioorganicheskaya Khimiya, 3(1), 120-126 (1977): Chemical Abstracts, 86, 1216783 (1977).
Haystead et al., “[gamma]-Phosphate-linked ATP-Sepharose for the Afinity Purification of Protein Kinases—Rapid Purification to Homogeneity of Sketetal Muscle Mitogen-Activated Protein Kinase Kinase,” European Journal of Biochemistry, 214(2), 459-467 (Jun. 1993).
Bressi, J.C., et al., “Adenosine Analogues as Selective Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase ofTrypanosomatidaevia Structure-Based Drug Design,”J. Med. Chem. 2001, pp. 2080-2093, vol. 44.
Chang, Y.-T., et al., “Synthesis and Application of Functionally Diverse 2,6,9-Trisubstituted Purine Libraries as CDK Inhibitors,”Chemistry BiologyJun. 1999; pp. 361-375, vol. 6, No. 6.
Halbfinger, E., et al., “Molecular Recognition of Modified Adenine Nucelotides by the P2Y1-Receptor. 1. A Synthetic, Biochemical, and NMR Approach,”J. Med. Chem. 1999, pp. 5325-5337, vol. 42, No. 26.
Hernandez, A-I., et al., “Acyclic Nucleotide Analogues as Novel Inhibitors of Human Mitochondrial Thymidine Kinase,”J. Med. Chem. 2002, pp. 4254-4263, vol. 45, No. 19.
Huryn, D.M., et al., “Synthesis of ISO-DDA, Member of a Novel Class of Anti-HIB Agents,”Tetrahedron Letters1989, pp. 6259-6262, vol. 30, No. 46, Printed in Great Britain by Pergamon Press plc.
Van Tilburg, E.W., et al., “N6, 5′-Disubstituted Adensine Derivatives as Partial Agonists for the Human Adenosine A3Receptor,”J. Med. Chem. 1999, pp. 1393-1400, vol. 42, No. 8.
Guiller, F., et al., “Linkers and Cleavage Strategies in Solid-Phase Organic Synthesis and Combinatorial Chemistry,”Chem. Rev. 2000, pp. 2091-2157, vol. 100, No. 6 (XP-002248255).
Kumar, P., et al., “A Versatile Solid Phase Method for the Synthesis of Oligonucleotide-3′-Phosphates,”Tetrahedron Letters, 1991, pp. 967-970, vol. 32, No. 7 (XP-002112931).
Vyle, J.S., et al., “A Novel Solid Support for Synthesis of 2′, 3′-Cyclic Phosphate Terminated Oligonucleotides,”Tetrahedron Letters, 1998, pp. 7975,7978, vol. 39 (XP004137857).
Graves, P.R., et al., “Discovery of Novel Targets of Quinoline Drugs in the Human Purine Binding Proteome,”Molecular Pharmacology, 2002, pp. 1364-1372, vol. 62(6).
Hall Steven E.
Hardeman Klass P.
Hinkley Lindsay A.
Jenks Matthew G.
Ware Roy W.
Alston & Bird LLP
Crane L. E.
Serenex, Inc.
LandOfFree
Alkyl-linked nucleotide compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Alkyl-linked nucleotide compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alkyl-linked nucleotide compositions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2772661