Sustained-release, oral pharmaceutical formulations and...

Details Sustained-release, oral pharmaceutical formulations and... Sustained-release, oral pharmaceutical formulations and...

2011-03-01

2011-03-01

Wax, Robert A (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C514S650000

Reexamination Certificate

active

07897173

ABSTRACT:
A sustained-release, oral pharmaceutical formulation of tramadol comprising a compound formed in situ of tramadol or a tramadol salt and a pharmaceutically acceptable acidic substance. The compound formed in situ has a desired water solubility. Also provided are methods of treatment using the pharmaceutical formulations. Method for preparing such formulations are also provided. The preparation method comprises repeatedly mixing tramadol or its salt with the acidic substance, and moistening the mixture and formulating the mixture under an energy input, such as heat or pressure. Optionally, drying, repeated granulating, extrudation and pelleting may also be included.

REFERENCES:
patent: 5516803 (1996-05-01), Raffa
patent: 5776492 (1998-07-01), Betzing et al.
patent: 5914129 (1999-06-01), Mauskop
patent: 5958452 (1999-09-01), Oshlack et al.
patent: 19927688 (2000-12-01), None
patent: 0546676 (1993-06-01), None
Hackh's Chemical Dictionary, 1969, McGraw-Hill, pp. 171-172.

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