Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds hormone or other secreted growth regulatory factor,...
Reexamination Certificate
2011-03-08
2011-03-08
Bunner, Bridget E (Department: 1646)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds hormone or other secreted growth regulatory factor,...
C530S388100, C530S389100, C530S350000
Reexamination Certificate
active
07901686
ABSTRACT:
The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
REFERENCES:
patent: 4774322 (1988-09-01), Seyedin et al.
patent: 4814433 (1989-03-01), Fredrickson
patent: 5223408 (1993-06-01), Goeddel et al.
patent: 5585087 (1996-12-01), Lustig et al.
patent: 5789543 (1998-08-01), Ingham et al.
patent: 5837538 (1998-11-01), Scott et al.
patent: 5844079 (1998-12-01), Ingham et al.
patent: 6165747 (2000-12-01), Ingham et al.
patent: 6261786 (2001-07-01), Marigo et al.
patent: 6271363 (2001-08-01), Ingham et al.
patent: 6384192 (2002-05-01), Ingham et al.
patent: 6576237 (2003-06-01), Ingham et al.
patent: 6607913 (2003-08-01), Ingham et al.
patent: 6610656 (2003-08-01), Ingham et al.
patent: 6630148 (2003-10-01), Ingham et al.
patent: 6664075 (2003-12-01), Ingham et al.
patent: 6884775 (2005-04-01), Tabin et al.
patent: 7060450 (2006-06-01), Tabin et al.
patent: 7144732 (2006-12-01), Ingham et al.
patent: 7220838 (2007-05-01), Beachy et al.
patent: 2004/0224882 (2004-11-01), Ingham et al.
patent: 2007/0213273 (2007-09-01), Ingham et al.
patent: WO 90/02809 (1990-03-01), None
patent: WO 92/15679 (1992-09-01), None
Wells (1990) Biochemistry 29(37): 8509-8517.
Ngo et al (1994) “The Protein Folding Problem and Tertiary Structure Prediction, Chapter 14: Computational Complexity Protein Structure Prediction, and the Levinthal Paradox” pp. 433-440 and 492-495 only.
Bork (2000) Genome Research 10:398.
Skolnick et al (2000) Trends in Biotech. 18(1): 34.
Doerks et al (1998) Trends in Genetics 14(6): 248.
Smith et al (1997) Nature Biotechnology 15:1222.
Brenner (1999) Trends in Genetics 15(4): 132.
Bork et al (1996) Trends in Genetics 12(10): 425.
Vaerman et al, 1971. J Immunol. 107(1): 201-211.
Campbell (1984. Monoclonal Antibody Technology; Chapter 1 of Laboratory Techniques in Biochemistry and Molecular Biology, vol. 13; pp. 1-33).
Benjamini et al, 1991. Immunology: A Short Course, 2nd edition. p. 40.
Brandon et al (1985. Journal of Histochemistry and Cytochemistry. 33(7): 715-719).
Zardoya et al., “Evolution and orthology of hedgehog genes”, Trends in Genetics. 12(12): 496-497. 1996.
Bowie et al., “Deciphering the Message in the Protein Sequences: Tolerance to Amino Acid Substitutions”, Science 247:1306-1310. 1990.
Creighton, T.E. Proteins Structures and Molecular Principles, W.H. Freeman and Company: New York, N.Y. pp. 223-227. 1984.
Dingermanse, M.A. et al., “The expression of liver-specific genes with rat embryonic hepatocytes in a discontinuous process”, Differentiation 56: 153-162. 1994.
Lemer, R.A., Antibodies of predetermined specificity in biology and medicine, Adv. Immunol., 36: 1-44. 1984.
Sampedro, J. and Guerrero, I., “Unrestricted expression of theDrosophilagene patched allows a normal segment polarity”, Nature., vol. 353, pp. 187-190 (1991).
To, L.P., et al., “Development and Characterization of a Whole-Cell Radioligand Binding Assay for [125I]gp120 of HIV-1”, Journal of Immunoassay, vol. 13(1), pp. 61-83 (1992).
Verma, U. and Laumas, K., “Screening of anti-progestins using in vitro human uterine progesterone receptor assay system”, Journal of Steroid Biochemistry, vol. 14(8), pp. 733-740 (1981).
Guo et al., “Protein Tolerance to Random Amino Acid Change” PNAS, 101(25), pp. 9205-9210 (2004).
Miao et al., “Sonic Hedgehog Promotes the Survival of Specific CNS Neuron Populations and Protects These Cells From Toxic Insult in Vitro”, The Journal of Neuroscience, 17(15) pp. 5891-5899 (1197).
Traiffort et al., “Regional Distribution of Sonic Hedgehog, Patched, and Smoothened MRNA in the Adult Rat Brain”, Journal of Neurochemistry, 70(3), pp. 1327-1330 (1998).
U.S. Appl. No. 11/894,601, filed Aug. 20, 2007, Tabin et al.
Bone et al., Endo. Meta. 2:160-184 (1995).
Bumcrot, D.A. and McMahon, A., “Somite differentiation. Sonic signals somites”, Curr. Biol., vol. 5(6), pp. 612-614 (1995).
Bumcrot, D.A. et al., “Proteolytic processing yields two secreted forms of sonic hedgehog”, Mol. Cell. Bio., vol. 15(4), pp. 2294-2303 (1995).
Charite, J. et al., “Ectopic Expression of Hoxb-8 Causes Duplication of the ZPA in the Forelimb and Homeotic Transformation of Axial Structures”, Cell, vol. 78, pp. 589-601 (1994).
Coffman et al., “Xotch, the Xenopus homolog ofDrosophilanotch”, Science, vol. 249, pp. 1438-1441 (1990).
Concordet, J. and Ingham, P., Developmental biology. Patterning goes sonic:, Nature, vol. 375(6529), pp. 279-280 (1995).
Currie et al., “Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish”, Nature, vol. 383, pp. 452-455 (1996).
Curry et al., “Sequence analysis reveals homology between two proteins of the flagellar radial spoke”, Mol. Cell. Bio., vol. 12, pp. 3967-3977 (1992).
Davidson, E.H., “How embryos work: a comparative view of diverse modes of cell fate specification”, Devel., vol. 108, pp. 365-389 (1990).
Davis, A.P. and M.R. Capecchi, “Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-1”, Devel., vol. 120, pp. 2187-2198 (1994).
Dickinson, W., “Molecules and morphology: Where's the homology”, TIG, vol. 11(4), pp. 119-120 (1995).
Dolle et al., “Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation”, Nature, vol. 342, pp. 767-772 (1989).
Dolle et al., “Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs”, Cell, vol. 75, pp. 431-441 (1993).
Echelard et al., “Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity”, Cell, vol. 75, pp. 1417-1430 (1993).
Ekker et al., “Distinct expression and shared activities of members of the hedgehog gene family of xenopus laevis”, Devel., vol. 121(8), pp. 2337-2347 (1995).
Ericson et al., “Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube”, Cell, vol. 81(5), p. 747-756 (1995).
Ettelaie et al., “The effect of lipid peroxidation and lipolysis on the ability of lipoproteins to influence thromboplastin activity”, Biochim. Biophys. Acta., vol. 1257(1), pp. 25-30 (1995).
Fahrner et al., Transcription of H-2 and Qa genes in embryonic and adult mice, EMBO J., vol. 6, pp. 1265-1271 (1987).
Fallon et al., “FGF-2: Apical ectodermal ridge growth signal for chick limb development”, Science, vol. 264, pp. 104-107 (1994).
Fan et al., “Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway”, Cell, vol. 81, pp. 457-465 (1995).
Fietz et al., “The hedgehog gene family inDrosophilaand vertebrate development”, Devel. Supp., pp. 43-51 (1994).
Forbes et al., “Genetic analysis of hedgehog signalling in theDrosophilaembryo”, Develop., vol. 119 (Supp.), pp. 114-124 (1993).
Ingham, “Signalling by hedgehog family proteins inDrosophilaand vertebrate development,” Curr. Opin. Genet. Dev. 5(4):478-484 (1995).
Iwamoto et al., “Actions of hedgehog proteins on skeletal cells”, Crit. Rev. Oral Biol. Med., vol. 10(4), pp. 477-486 (1999 (abstract).
Iwasaki et al., “Age-dependent effects of hedgehog protein on chondrocytes”, J. Bone Joint Surg. Br., vol. 81(6), pp. 1076-1082, (1999).
Katsuura et a
Ingham Philip W.
Marigo Valeria
McMahon Andrew P.
Tabin Clifford
Bunner Bridget E
Howard Zachary C
Imperial Cancer Research Technology Ltd.
President and Fellows of Harvard College
Ropes & Gray LLP
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