Methods compositions and compound assays for inhibiting...

Details Methods compositions and compound assays for inhibiting... Methods compositions and compound assays for inhibiting...

2011-03-22

2011-03-22

Stucker, Jeffrey (Department: 1649)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S069100, C435S007210, C435S007900, C435S007910, C435S007200, C435S007800, C435S008000, C435S070300

Reexamination Certificate

active

07910320

ABSTRACT:
A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.

REFERENCES:
patent: 5998164 (1999-12-01), Li et al.
patent: 6090575 (2000-07-01), Li et al.
patent: 6653086 (2003-11-01), Behan et al.
patent: 7163800 (2007-01-01), Oakley et al.
patent: 7429459 (2008-09-01), Merchiers et al.
patent: 2002/0082412 (2002-06-01), Brennand et al.
patent: 2003/0044898 (2003-03-01), Li et al.
patent: 2003/0113798 (2003-06-01), Burmer et al.
patent: 2004/0093626 (2004-05-01), Brennand et al.
patent: 2005/0118639 (2005-06-01), Hinuma et al.
patent: 01/90128 (2001-11-01), None
patent: 02/068579 (2002-09-01), None
patent: 03/097795 (2003-11-01), None
patent: 2004/042405 (2004-05-01), None
Kostenis et al. Trends in Pharmacological Science 2005. 26: 595-602.
Kostenis et al.; TRENDS in Pharmacological Sciences “Techniques: Promiscuous Gα proteins in basic research and drug discovery” Nov. 2005, vol. 26, No. 11.
Mark E. Fortini; Nature Reviews/Molecular Cell Biology “γ-Secretase-Mediated Proteolysis in Cell-Surface-Receptor Signalling” vol. 3; Sep. 2002.

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