Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2011-03-22
2011-03-22
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
Reexamination Certificate
active
07910324
ABSTRACT:
The present invention provides a method of screening for compounds which affect the processing of EphA4 by γ-secretase, which includes the following steps:(i) contacting a first biological composition containing γ-secretase or a biologically active fragment thereof with a second biological composition containing EphA4 in the presence and absence of a candidate compound;(ii) measuring the cleavage of the EphA4 in the presence and absence of the candidate compound;(iii) selecting those candidate compounds which affect the cleavage of the EphA4 by γ-secretase; and(iv) identifying the candidate compounds selected in step (iii) as compounds which affect the processing of EphA4 by γ-secretase.
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Clark & Elbing LLP
EISAI R&D Management Co., Ltd.
Gitomer Ralph
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