Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Reexamination Certificate
2008-01-08
2008-01-08
Rao, Manjunath N. (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
C424S198100, C435S069400, C435S320100, C530S398000, C536S023200, C536S023500, C536S023510
Reexamination Certificate
active
07317095
ABSTRACT:
The inventors have designed novel FSH mutants with increased glycosylation and longer half-lives for use in inducing folliculogenesis in human patients. The use of a FSH mutant preparation of the invention permits the use of lower cumulative doses of FSH to achieve the same or better clinical result.
REFERENCES:
patent: 5792460 (1998-08-01), Boime
patent: WO 88/10270 (1988-12-01), None
patent: WO 96/07750 (1996-03-01), None
patent: WO 01/58493 (2001-08-01), None
Bello et al., Cloning and DNA sequence analysis of the cDNA for the common alpha subunit of the ovine pituitary glycoprotein hormones, 1989, Nucleic acids Research, vol. 17, No. 24, pp. 10494.
Rathnam et al., Isolation and amino acid sequence of the alpha subunit of follicle-stimulating hormone from equine pituitary glands, 1978, The Journal of Biological Chemistry, vol. 253, Issue 15, pp. 5355-5362.
Bishop et al., Both the beta-subunit carbohydrate residues of follicle-stimulating hormone determine the metabolic clearance rate and in Vivo potency, 1995, vol. 136, No. 6, pp. 2635-2640.
Bousfield et al., Structural features of mammalian gonadotropins, 1996, Molecular and Cellular Endocrinology, vol. 125, pp. 3-19.
Wang et al., Rapid analysis of gene expression (RAGE) facilitates universal expression profiling, 1999, Nucleic acids Research, vol. 27, No. 23, pp. 4609-4618.
Kaufman et al., Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome, 1999, vol. 94, No. 9, pp. 3178-3184.
Baird, D., Is there a place for different isoforms of FSH in clinical medicine, 2001, Human Reproduction, vol. 16, Issue 7, pp. 1316-1318.
Macklon et al., Follicule-Stimulating Hormone and advanced follicle development in the human, 2001, Archives of Medical Research, vol. 32, pp. 595-600.
Palagiano et al., FSH: urinary and recombinant, 2004, European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 115S, pp. S30-S33.
Fox, et al., “Three-Dimensional Structure of Human Follicle-Stimulating Hormone”, Molecular Endocrinology. (2001), vol. 15, No. 3, 378-389.
Jiang, et al., “Structural Predictions for the Ligand-Binding Region of Glycoprotein Hormone Receptors and the Nature of Hormone-Receptor Interactions”, Structure. (Dec. 15, 1995), vol. 3, No. 12, 1341-1353.
Lapthorn, et al., “Crystal Structure of Human Chorionic Gonadotropin”, Nature. (Jun. 9, 1994), vol. 369, 455-461.
Tegoni, et al., “Crystal Structure of a Temary Complex Between Human Chorionic Gonadotropin (hCG) and Two Fv Fragments Specific for the Alpha and Beta-Subunits”, Journal of Molecular Biology.( Jun. 25, 1999), vol. 289, No. 5, 1375-1385, Abstract.
Wu, et al., “Structure of Human Chorionic Gonadotropin at 2.6 Å Resolution from MAD Analysis of the Selenomethionyl Protein”, Structure. (Jun. 15, 1994), vol. 2, No. 6, 545-558.
Brondyk William H.
Campbell Robert
Jiang Xuliang
Applied Research Systems ARS Holding N.V.
Browdy & Neimark PLLC
Dang Ian
Rao Manjunath N.
LandOfFree
Mutant glycoproteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mutant glycoproteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mutant glycoproteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2754130