Method and composition for arresting angiogenesis and capillary,

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 56, 514169, 514179, A61K 3170, A61K 31725, A61K 3156

Patent

active

049668900

ABSTRACT:
A composition and method for arresting angiogenesis, and cell, capillary or membrane leakage comprising a pharmaceutically effective amount of angiostatic steroid and pentosan polysulfate, or a salt thereof, having the formula: ##STR1## wherein X is at least one member selected from the group consisting of H and --SO.sub.3 Y, and Y is at least one member selected from the group consisting of H and a pharmaceutically acceptable cation.

REFERENCES:
patent: 4510084 (1985-04-01), Eibl et al.
patent: 4656161 (1987-04-01), Herr
patent: 4699900 (1987-10-01), Bayol et al.
patent: 4713373 (1987-12-01), Bayol et al.
patent: 4738955 (1988-04-01), Landsberger
patent: 4820693 (1989-04-01), Gillespie
"Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin in the Presence of Cortisone", by Folkman et al., Science; Aug. 1983, pp. 719-725.
"Vascularization Induced in the Cheek Pouch of the Syrian Hamster by Tumor and Nontumor Substances", by Shubik et al., Journal of the National Cancer Institute, vol. 57; Oct. 1976, pp. 769-774.
"Toward a New Understanding of Vascular Proliferative Disease in Children", by Folkman, Pediatrics, vol. 74; Nov. 5, 1984, pp. 850-856.
"Anti-Angiogenesis by Steroids without Glucocorticoid or Mineralocorticoid Activity in the Presence of Heparin", by Crum et al., Journal of Cell Biology; Oct. 1984, Abstract No. 581, p. 158a.
"Successful Treatment of Interstitial Cystitis with Sodium Penetosanpolysulfate", by Parsons et al., Journal of Urology; 1983, pp. 51-53.
"The Effect of Pentosan Polysulfate (SP54) on the Fibrinolytic System of Man" by Marsh et al., IX International Congress on Thrombosis and Hemostasis--Stockholm, 1983, Abstract 0246.
"A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment", by Crum et al., Science; Dec. 20, 1985, pp. 1375, 1378.
"The Use of Dimethyl Sulfoxide in the Treatment of Intractable Urinary Frequency", by Okamura et al., Acta Urol., Japan, vol. 31(4); 1985, pp. 627-632.
"Prospective Study of Intravesical Dimethyl Sulfoxide in Treatment of Suspected Early Interstitial Cystitis", by Fowler, Urology, vol. 18(1); Jul. 1981, pp. 21-26.
"Pharmacologic and Biochemical Considerations of Dimethyl Sulfoxide", by Wood et al., Annals New York Academy of Sciences; vol. 243; 1975, pp. 7-19.
"Studies on the Modifying Effect of Dimethyl Sulfoxide and Other Chemicals on Experimental Skin Tumor Induction", by Stenback et al., Annals New York Academy of Sciences, vol. 243; 1975, pp. 209-227.
"Antibiotic-Induced Interstitial Cystitis: An Auto-Immune Phenomenon", by Gillespie et al., Abstract No. 108, published Jul. 16, 1984.
"Antibiotic-Induced Interstitial Cystitis: A Model for Cell Membrane Instability", by Gillespie et al., American Urol. Assoc., Journal of Urology, 80th Annual Meeting of the AUA in Atlanta, Ga., Apr. 10, 1985.
"Immune-Mediated Angiogenesis Inhibition through SP54 and Prednisone in Antibiotic-Related Interstitial Cystitis", by Gillespie et al., published in Apr., 1986, in the Journal of Urology, vol. 135.
"Antibiotic-Related Interstital Cystitis: A Leaky Cell Membrane Disease", by Gillespie et al., presented at 1986 meeting of American College of Obstetricians and Gynecologists.
Folkman et al., Science, 8/19/1983, pp. 719-725.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and composition for arresting angiogenesis and capillary, does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and composition for arresting angiogenesis and capillary,, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and composition for arresting angiogenesis and capillary, will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-275353

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.