Crystal structure β 2 adrenoreceptor

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical

Reexamination Certificate

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Details

C702S027000, C436S086000

Reexamination Certificate

active

07912654

ABSTRACT:
A computer readable medium comprising atomic coordinates for the human β2adrenoreceptor is provided. The computer readable medium programming for displaying a molecular model of the human β2adrenoreceptor, programming for identifying a compound that binds to said human β2adrenoreceptor and/or a database of structures of known test compounds. Also provided is a method comprising computationally identifying a compound that binds to the human β2adrenoreceptor using the atomic coordinates.

REFERENCES:
patent: 2005/0203131 (2005-09-01), Mammen et al.
patent: 01/81627 (2001-11-01), None
Cohen et al. Molecular Modeling software and material for medicinal chemmistry. J. Med. Chem. 1990, 33 (3), 883-894.
Spina et al. beta2-Adrenoceptor agonist. In Drugs for the Treatment of Respiratory Diseases (2003) Editor(s): Spina, Domenico pp. 56-104, Cambridge University Press: Cambridge, UK.
Wiencek, J. M. New Strategies for Protein Crystal Growth. Ann. Rev. Biomed. Eng. 1999, 1, 505-534).
Cherezov; et al., “High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor”, Science, Nov. 23, 2007, 318(5854):1258-65.
Rasmussen; et al., “Crystal structure of the human beta2 adrenergic G-protein-coupled receptor”, Nature, Nov. 15, 2007, 450(7168):383-7.
Rosenbaum; et al., “GPCR Engineering Yields High-Resolution Structural Insights into b2-Adrenergic Receptor Function”, Science, Nov. 23, 2007, 318:1266-1273.

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