Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Reexamination Certificate
2008-04-29
2008-04-29
Bunner, Bridget E (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
C530S350000, C435S069700
Reexamination Certificate
active
07365171
ABSTRACT:
The present invention provides chemokine-like factor (CKLF) polypeptides with chemotactic and hematopoietic stimulating activities and polynucleotides encoding such polypeptides. Additionally, a method for producing such CKLF polypeptides by recombinant techniques is provided. Also provided are the antibodies and antagonists against such polypeptides. The present invention further disclose a drug compound comprising a therapeutically effective amount of such CKLF polypeptides as well as pharmaceutically acceptable excipients and carriers. Also disclosed are the uses of such CKLF polypeptides and polynucleotides in diagnostics or therapeutics to treat immunodeficiency, hematopoietic diseases and primary tumors.
REFERENCES:
patent: 6548633 (2003-04-01), Edwards et al.
patent: 6573068 (2003-06-01), Milne Edwards et al.
patent: WO 9925825 (1999-05-01), None
Han et al. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. Biochem J 357: 127-135, 2001.
Ke et al. Effects of novel human chemokine-like factor 1 (CKLF1) on bone marrow hematopoietic stem cell/progenitor cell in vitro. Zhonghua Xue Ye Xue Za Zhi 23(6):301-303, 2002. Abstract only.
Chen Guanghui
Di Chunhui
Han Wenling
Huang Jiaqiang
Ma Dalong
Beijing Medical University
Beijing Medical University United Biological Engineering Company
Bunner Bridget E
Li Yi
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