CDNA and genes for human angiogenin (angiogenesis factor) and me

Details CDNA and genes for human angiogenin (angiogenesis factor) and me CDNA and genes for human angiogenin (angiogenesis factor) and me

1989-02-02

1990-10-30

Mays, Thomas D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4351723, 43524025, 4352523, 435320, 530399, 536 27, 935 13, 935 14, 935 28, 935 29, 935 70, 935 71, 935 73, C12N 922, C12N 1500, C07K 300, C07H 1512

Patent

active

049668498

ABSTRACT:
DNA sequences encoding a protein having angiogenic activity and mutated DNA sequences encoding a protein having decreased angiogenic activity are disclosed. Expression vectors containing these wild-type or mutated sequences are introduced into host cells and direct the production of wild-type or mutant angiogenic proteins. Proteins produced according to the invention are useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnostic and therapeutic purposes. Mutant proteins produced according to the invention are useful therapeutic compositions as angiogensis inhibitors, which may retard tumor growth by inhibiting the development of a hemovascular network.

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