Glycopegylated erythropoietin

Details Glycopegylated erythropoietin Glycopegylated erythropoietin

2008-07-29

2008-07-29

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S395000

Reexamination Certificate

active

07405198

ABSTRACT:
The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

REFERENCES:
patent: 4055635 (1977-10-01), Green et al.
patent: 4088538 (1978-05-01), Schneider
patent: 4179337 (1979-12-01), Davis et al.
patent: 4385260 (1983-05-01), Watts et al.
patent: 4412989 (1983-11-01), Iwashita et al.
patent: 4414147 (1983-11-01), Klibanov
patent: 4496689 (1985-01-01), Mitra
patent: 4806595 (1989-02-01), Noishiki et al.
patent: 4925796 (1990-05-01), Bergh et al.
patent: 5154924 (1992-10-01), Friden
patent: 5182107 (1993-01-01), Friden
patent: 5352670 (1994-10-01), Venot
patent: 5374541 (1994-12-01), Wong
patent: 5405753 (1995-04-01), Brossmer
patent: 5432059 (1995-07-01), Bean
patent: 5527527 (1996-06-01), Friden
patent: 5545553 (1996-08-01), Gotschlich
patent: 5614184 (1997-03-01), Sytkowski et al.
patent: 5621039 (1997-04-01), Hallahan et al.
patent: 5672683 (1997-09-01), Friden et al.
patent: 5716812 (1998-02-01), Withers et al.
patent: 5728554 (1998-03-01), Bayer et al.
patent: 5833988 (1998-11-01), Friden
patent: 5834251 (1998-11-01), Maras et al.
patent: 5876980 (1999-03-01), DeFrees et al.
patent: 5922577 (1999-07-01), Defrees et al.
patent: 5932462 (1999-08-01), Harris et al.
patent: 5969040 (1999-10-01), Hallahan et al.
patent: 5977307 (1999-11-01), Friden
patent: 6015555 (2000-01-01), Friden
patent: 6030815 (2000-02-01), DeFrees et al.
patent: 6037452 (2000-03-01), Minamino et al.
patent: 6057292 (2000-05-01), Cunningham et al.
patent: 6096512 (2000-08-01), Elhammer et al.
patent: 6166183 (2000-12-01), Ishikawa et al.
patent: 6183738 (2001-02-01), Clark
patent: 6692931 (2004-02-01), Reutter et al.
patent: 7202208 (2007-04-01), Papadimitriou
patent: 2002/0037841 (2002-03-01), Papadimitriou
patent: 2002/0115833 (2002-08-01), Burg et al.
patent: 2002/0137134 (2002-09-01), Gerngross et al.
patent: 0605963 (1994-07-01), None
patent: WO 87/00056 (1987-01-01), None
patent: WO 89/10134 (1989-11-01), None
patent: WO 90/07572 (1990-07-01), None
patent: WO 92/18135 (1993-05-01), None
patent: WO 94/05332 (1994-03-01), None
patent: WO 94/15625 (1994-07-01), None
patent: WO 95/02421 (1995-01-01), None
patent: WO 96/40731 (1996-06-01), None
patent: WO 96/32491 (1996-10-01), None
patent: WO 97/05330 (1997-02-01), None
patent: WO 98/05363 (1998-02-01), None
patent: WO 87/05330 (1998-07-01), None
patent: WO 98/31826 (1998-07-01), None
patent: WO 98/58694 (1998-12-01), None
patent: WO 99/22764 (1999-05-01), None
patent: WO 99/00150 (1999-07-01), None
patent: WO 00/65087 (2000-11-01), None
patent: WO 01/49830 (2001-07-01), None
patent: WO 01/60411 (2001-08-01), None
patent: WO 02/02597 (2002-01-01), None
patent: WO 02/13843 (2002-02-01), None
patent: WO 02/13873 (2002-02-01), None
patent: WO 02/074806 (2002-09-01), None
Cointe et al, Unusual N-glycosylation of a recombinant human erythropoietin expressed in a human lymphoblastoid cell line does not alter its biological properties, Glycobiology (2000), vol. 10, 511-519.
Abuchowski et al., 1977, J. Biol. Chem. 252:3582-2586.
Abuchowski et al., 1984, Cancer Biochem. Biophys. 7:175-186.
Abuchowski et al., 1977, J. Biol. Chem. 252:3578-3581.
Ailor et al., 2000, Glycobiology 10:837-847.
Altmann et al., 1999, Glycoconjugate J. 16:109-123.
Aplin et al., 1981, CRC Crit Rev. Biochem. 259-306.
Beauchamp et al., 1983, Anal Biochem. 131:25-33.
Berger et al., 1988 71:1641-1647.
BErg-Fassman et al. 1993, J. Biol. Chem. 268:14861-14866.
Bhadra et al., 2002, Pharmazie 57:5-29.
Bhatia et al., 1989, Anal. Biochem. 178:408-413.
Bickel et al., 2001, Adv. Drug Deliv. Rev. 46:247-279.
Bjoern, et al., 1992, J. Biol. Chem., 266(17):11051-11057.
Boccu et al., 1983, Z. Naturforsch 38C:94-99.
Boime et al., 1995, Endocrinology 136:2635-2640.
Boissel et al., 1993, J. Biol. Chem. 268:15983-15993.
Bouizar et al., 1986, Eur. J. Biochem. 155:141-147.
Boyd et al, 1995, Mol. Immunol. 32:1311-1318.
Browning et al., 1989, J. Immunol. 143:1859-1867.
Buckmann et al., 1981, Makromol. Chem. 182:1379-1384.
Burns et al., 2002, Blood 99:4400-4405.
Busterbosch et al., 1996, Eur. J. Biochem. 237:344-349.
Butnev et al., 1998, Biology of Reproduction 58:458-469.
Byun et al., 1992, ASAIO Journal M649-M653.
Casares et al., 2001, Nature Biotech 19:142-147.
Chaffee et al., 1992, J. Clin. Invest 89:1643-1651.
Charter et al., 2000, Glycobiology 10:1049-1056.
Chern et al., 1991, Eur. J. Biochem. 2002:225-229.
Chiba et al., 1995, Biochem J. 308:405-409.
Chrisey et al., 1996, Nucleic Acids Res. 24:3031-3039.
Clark, et al., 1996, J. Biol. Chem,271(36)21969-21977.
Cointe, et al., 2000, Glycobiology, 10(5):511-519.
Conradt et al., 1987, J. Biol. Chem. 262:14600-14605.
Copeland, Robert A., 2000, Enzymes, Second Edition, 146-150.
Crout et al., 1998, Curr. Opin. Chem. Biol. 2:98-111.
Degado et al., 1992, Critical Reviews in Therapeutic 9:249-304.
Delgaldo et al., Biotechnol. Appl. Biochem. 12:119-128.
Detty et al., 1982, J. Org. Chem. 47:5416-5418.
Dunn et al., 1991, Rds. Polymeric Drugs and Drug Delivery Systems, ACS Symposium Series vol. 469, American Chemical Society, Washington D.C.
Durieux, et al., 2001, Tetrahedron Letters, 42:2297-2299.
Dwek et al., 1995, J. Anat. 187:279-292.
Eavarone et al., 2000, J. Biomed Mater. Res. 51:10-14.
Fibi et al., 1995, Cells Blood 85:1229-1236.
Fischer et al., 1998, Thrombosis Research 89:147-150.
Flynn et al., 2000, Curr. Opin. Oncol. 12:574-581.
Garnett et al., 2002, Advanced Drug Delivery Reviews 53:171-216.
Gatot, et al., 1998, J. Biol. Chem., 273(21):12870-12880.
Gillis et al., 1988, Behring Inst. Mitt. Aug. 83:1-7.
Ginns, Dr. Edward, PEG Glucocerebrosidase, Internet page from www.gaucher.org.uk/peg2.prg, printed Jun. 21, 2002.
Grodberg et al., 1993, Eur. J. Biochem. 218:597-601.
Gross, H.J., 1992, Eur. J. Bioche,. 203(1-2):269-275.
Hall et al., 2001, Methods in Molecular Biology 166:139-154.
Haneda et al., Carbohydr. Res. 292:61-70.
Hang et al., 2001, J. Am. Chem. Soc. 123:1242-1243.
Harris, 1985, Macronol. Chem. Phys. C25: 325-373.
Hellstrom et al., 2001, Methods in Molecular Biology 166:3-16.
Hermanson et al., 1992, Immobilized Affinity Ligand Techniques, Academic Press.
Hermanson, 1996, Bioconjugate Techniques, Academic Press, San Diego.
Hills et al., 2002, American Biotechnology Laboratory, 20(11):30.
Hollister et al., 2001, Glycobiology 11:1-19.
Hounsell et al., 1996, Glycoconj. J. 13:19-26.
Ichikawa et al., 1992, J. Am. Chem. Soc. 114:9283-9298.
Inoue et al., 1995, Biotechnology Annual Review 1:297-313.
Ito et al., 1992, Pure Appl. Chem. 65:753-762.
Jackson et al., 1987, Anal. Biochem. 165:114-127.
Jarvis et al., 1998, Curr, Opin, Biotechnol. 9:528-533.
Joppich et al., 1979, Makromol Chem. 180:1381-1384.
Joshi et al., 1990, J. Biol. Che,. 265:14518-14525.
Jung et al., 1983, Biochem. Biophys. Acta, 761:152-162.
Kalsner et al., 1995, Glycoconj. J. 12:360-370.
Kasina et al., 1998 Bioconjugate Chem., 9:108-117.
Katre et al., 1987, Proc. Natl. Acad. Sci. U.S.A. 84:1487-1491.
Keppler et al., 2001, Glycobiology 11:11R-18R.
Kitamura et al., 1990, Biochem. Biophys. Res. Commun. 28:1387-1394.
Kitamura et al., 1991, Cancer Res. 51:4310-4315.
Kodama et al., 1993, Tetrahedron Lett. 34:6419-6422.
Koeller et al., 2000, Nature Biotechnology 18:835-841.
Koide et al., 1983, Biochem Biophys. Res. Commun. 111:659-667.
Kreitmann 2001, Current Pharaceutical Biotechnology 2:313-325.
Kuhn, et al., 1995, J. Biol. Chem. 270(49):29493-29497.
Lai et al, 1986, J. Biol. Che,. 261:3116-3121.
Lee-Huang et al., 1984, Proc. Natl. Acad. Sci. U.S.A. 81:2708-2712.
Lee et al., 1989, Biochemistry 28:1856-1861.
Li et al., 2002, Trends in Pharmacological Science 23:206-209.

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