Thrombin compositions

Details Thrombin compositions Thrombin compositions

2008-07-01

2008-07-01

Robinson, Hope A (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S007100, C530S300000, C530S350000

Reexamination Certificate

active

07393674

ABSTRACT:
Compositions comprising thrombin and methods of preparing them are disclosed. The composition may be in the form of an aqueous solution at pH 5.7-7.4 consisting essentially of 0.1 mg/mL to 5.0 mg/mL thrombin, 2% to 4% (w/v) sucrose, 3.5% to 5% (w/v) mannitol, 50 mM to 300 mM NaCl, 0-5 mM CaCl2, 0.03% to 1% (w/v) of a surfactant or high-molecular-weight polyethylene glycol, and a physiologically acceptable buffer, or may be in lyophilized form.

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Carpenter et al., “Ch. 5: Rational Design of Stable Lyophilized Protein Formulations: Theory and Practice,” pp. 109-133, inRational Design of Stable Protein Forumlations, Carpenter and Manning (eds.), Kluwer Academic / Plenum Publishers, New York, 2002.
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