Process for preparing optically active alcohols

Details Process for preparing optically active alcohols Process for preparing optically active alcohols

2011-06-07

2011-06-07

Berch, Mark (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S230000, C560S060000, C568S814000

Reexamination Certificate

active

07956182

ABSTRACT:
This invention relates to a process for producing optically active alcohols using asymmetric reduction of aromatic ketones. This process gives optically active alcohols in high enantioselectivity in a large scale production.

REFERENCES:
patent: 5189177 (1993-02-01), Blacklock et al.
patent: 5618707 (1997-04-01), Homann et al.
patent: 5631365 (1997-05-01), Rosenblum et al.
patent: 5856473 (1999-01-01), Shankar
patent: 5886171 (1999-03-01), Wu et al.
patent: 6090950 (2000-07-01), Heise
patent: 6133001 (2000-10-01), Homann et al.
patent: 6207822 (2001-03-01), Thiruvengadam et al.
patent: 6218585 (2001-04-01), Matos et al.
patent: 6627757 (2003-09-01), Fu et al.
patent: 2007/0259845 (2007-11-01), Kansal et al.
patent: WO 00/34240 (2000-06-01), None
patent: WO 2005/066120 (2005-07-01), None
Chen, Chinese Chemical Letters vol. 15, No. 2, pp. 167-168, 2004.
A Novel One-Step Diastereo- and Enantioselective Formation of trans-Azetidinones and Its Application to the Total Synthesis of Cholesterol Absorption Inhibitors, by G. Wu et al,J. Org. Chem., 1999, vol. 64, pp. 3714-3718.
Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption, by S. Rosenblum et al,J. Med. Chem., 1998, vol. 41, pp. 973-980.
Process for preparing Ezetimibe intermediate by an acid enhanced chemo- and enantioselective CBS catalyzed ketone reduction, by X. Fu et al, Tetrahedron Letters, 2003, vol. 44, pp. 801-804.
Highly enantioselective reduction of achiral ketones with NaBH4/Me3SiCl catalyzed by (S)-α,α-diphenylpyrrolidine-methanol, by B. Jiang et al, Tetrahedron Letters, 2000, vol. 41, pp. 10281-10283.

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