Organoselenium compounds for cancer chemoprevention

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S333000, C549S076000, C549S493000, C549S496000

Reexamination Certificate

active

07314929

ABSTRACT:
A compound containing an alkylene selenocyanate or an alkylene isoselenocyanate moiety effective to prevent the occurrence or progression of cancer or a precancerous condition. The compound can be provided and administered in the form of a pharmaceutical composition, a cosmetic, a food additive, supplement, or the like. Methods for synthesis and use of the chemopreventive compound of the invention are also provided.

REFERENCES:
patent: 4938949 (1990-07-01), Borch et al.
patent: 6166003 (2000-12-01), Lam
patent: 6703524 (2004-03-01), Lam et al.
Ahmed et al. “Sulfur and Selenium Bifunctional Organoselenium Compounds in Chemoprevention”, Presented at The 92ndAnnual Meeting of American Association for Cancer Research, Mar. 24-28, 2001, New Orleans, Louisiana and The Role of Chemistry in Biotechnology, Minnesota Section of American Chemical Society, Oct. 7, 2003 (14 pages).
Ahmed, Nayaz, “Bifunctional Organoselenium Compounds in Chemoprevention”, Grant Abstract, Grant No. IR43CA079266-01A1 [online]. National Cancer Institute, project dates May 7, 1999-May 6, 2000 [retrieved on Nov. 7, 2002]. Retrieved from the Internet: URL: http://commons.cit.nih.gov/crisp3/CRISP—LIB.getdoc?textkey=2867542&p—grant—num=IR43CA079266-01A1&p—query=&ticket=2234339&p—audit—session—id=11269607&p—keywords=, 1 page.
Anderson, “Determination of Glutathione and Glutathione Disulfide in Biological Systems,”Meth. Enzymol., 1985; 113:548-564.
Ashton et al., “The Self-Assembly and Dynamic Properties of Thiophene-Containing [2]Catenanes,”Synthesis, Dec. 1994; 12:1344-1352.
Ausubel et al., eds.,Current Protocols in Molecular Biology, vol. 1, Unit 2.2, John Wiley & Sons, New York, 1990, Cover page, Publication page, Table of Contents, and Unit 2.2.
Bird, “Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings,”Cancer Lett., 1987; 37:147-151.
Chesseaud, “The Role of Glutathione and Glutathione S-Transferases in the Metabolism of Chemical Carcinogens and other Electrophilic Agents,”Adv. Cancer. Res., 1979; 29:175-274.
Chung et al., “Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone α-hydroxylation and DNA methylation in rat liver,”Carcinogenesis, Apr. 1985; 6(4):539-543.
Damani et al., “Chapter 4: Oxidative Metabolism of Heterocyclic Ring Systems,”Metabolic basis of detoxification, Jakoby et al., eds, Academic Press, Oxford, 1983; 69-89.
Damani, “Chapter 7: Oxidation at Nitrogen Centers,”Metabolic basis of detoxification, Jakoby et al., eds, Academic Press, Oxford, 1983; 127-148.
El-Bayoumy et al., “Inhibition of 7,12-Dimethylbenz(α)anthracene-induced Tumors and DNA Adduct Formation in the Mammary Glands of Female Sprague-Dawley Rats by the Synthetic Organoselenium Compound, 1,4-Phenylenebis(methylene)selenocyanate,”Cancer Res., 1992; 52(9):2402-2407.
El-Bayoumy et al., “Chemoprevention of Cancer by Organoselenium Compounds,”Cell. Biochem., 1995; 22:92-100.
El-Bayoumy, “Effects of Organoselenium Compounds on Induction of Mouse Forestomach Tumors by Benzo(α)pyrene,”Cancer Res., Aug. 1985; 45(8):3631-3635.
El-Bayoumy et al., “Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenicity in mouse lung by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyantate,”Carcinogenesis, Jun. 1993; 14(6):1111-1113.
Ellman, “Tissue Sulfhydryl Groups,”Arch. Biochem. Biophys., 1959; 82:70-77.
Frejd et al., “Selenium-Containing Pancreatic Imaging Agents, Synthesis of β-2-and β-3-Selenienylelanine (1),”J. Heterocyclic Chem., 1980; 17:759-761.
Goodwin et al., “Selenium and Glutathione Peroxidase Levels in Patients with Epidermoid Carcinoma of the Oral Cavity and Oropharynx,”Cancer, Jan. 1, 1983; 51(1):110-115.
Guo et al., “Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enxymes and nitrosamine metabolism in rats,”Carcinogenesis, Dec. 1992; 13(12):2205-2210.
Habig et al., “Glutathione S-Transferases,”J. Biol. Chem., Nov. 25, 1974; 249(22):7130-7139.
Hecht et al., “Comparative Tumorigenicity and DNA Methylation in F344 Rats by 4-(Methylnitrosamino)-1-butanone and N-Nitrosodimethylamine,”Cancer Res., Feb. 1986; 46:498-502.
Hecht et al., “Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke,”Carcinogenesis, Jun. 1988; 9(6):875-884.
Henriksen et al., “One-Step Synthesis of Alkyl and Aryl Isoseleno-cyanates from Primary Amines,”Synthesis, Aug. 1976; 8:519-521.
Hoffmann et al., “Nicotine-derived N-Nitrosamines and Tobacco-related Cancer: Current Status and Future Directions,”Cancer Res., Mar. 1985; 45(3):935-944.
Hojjatie et al., “Synthesis and Multinuclear NMR Characterizations of Some [3.3]Diselena- and [4.4]Tetraselenacyclophanes,”Tetrahedron, 1989; 45(6):1611-1622.
Hojjatie et al., “Synthesis and Multinuclear NMR Characterization of Some [3.3]Diselena- and [4.4]Tetraselenacyclophanes,”CA 111:153774.
Ip et al., “Cancer chemoprevention by aliphatic selenocyanates: effect of chain length on inhibition of mammary tumors and DMBA adducts,”Carcinogeneis, Jan. 1995; 16(1):35-38.
Jacob et al., “Rat liver microsomal ring- and S-oxidation of thiaarenes with central or peripheral thiophene rings,”Toxicology, 1991; 67:181-194.
Jakoby et al., eds.,Metabolic Basis of Detoxication: Metabolism of Functional Groups, Academic Press, New York, 1982; Cover pg., Publication pg., and Table of Contents. (5 pgs.).
Katritzky et al., eds.,Comphrehensive Heterocyclic Chemistry, Pergamon Press, Oxford, 1984; 4(3):pvii-vii.
Kawamori et al., “Evaluation of benzyl selenocyanate glutathione conjugate for potential chemopreventive properties in colon carcinogenesis,”Int. J. Oncol., Jul. 1998; 13(1):29-34.
Kemal, “Importance of Heterocycles in Biochemical Pathways,”Comprehensive Heterocylic Chemistry vol. 1, Katritzky et al., eds., Perman Press, 1997, pp. 247-268.
Kjaer, “Chapter 34: Naturally occurring isothiocyanates and their parent glycosides,” inOrganic Sulfur Compounds, Kharasch ed., Pergamon Press, New York, 1961; 409-420.
Krisnaswamy et al., “A case control study of selenium in cancer,”Indian J. Med. Res. Sect. B., 1993; 98:124-128.
Lam, “Cancer Chemoprevention by Sulfur Compounds,” Grant Abstract, Grant No. 24836 Agency Code: SBIR [DIALOG: File 266:FEDRIP]. Health and Human Services, 1994. [retrieved on Aug. 12, 2002]. 1 pg.
Lam et al., “Chapter 22: Inhibition of Chemically Induced Carcinogenesis by 2-n-Heptylfuran and 2-n-Butyltiophene from Roast Beef Aroma,”Sulfur compounds in foods, Mussinan et al., ACS Symposium Series 564, p. 278-291, 1994.
Lam et al., “Effects of Circuit Limonoids on GlutathionS-Transferase Activity in Mice,”J. Agric. Food Chem., 1989; 37(4):878-880.
Lam et al., “Inhibition of Benzo[α]pyrine-Induced Forestomach Neoplasia in Mice by Citrus Limonoids,”Nutr. Cancer, 1989; 12(1):43-47.
Lam et al., “Inhibitory Effects of 2-n-Heptylfuran and 2-n-Butlythiophene on Benzo[α]Pyrene-Induced Lung and Forestomach Tumorigenesis in A/J Mice,”Nutr. Cancer, 1992; 17(1):19-26.
Lowry et al., “Protein Measurement with the Filin Phenol Reagent,”J. Biol. Chem., 1951; 193:265-275.
Mac Leod et al., “Capillary Gas Chromatography-Mass Spectrometric Analysis of Cooked Ground Beef Aroma,”J. Food Sci., 1986; 51(6):1427-1434.
Maga, “Potato Glycoalkaloids,”CRC Critical Reviews in Food Science and Nutrition, Jul. 1980; 12(4):371-405.
Mautner et al., “The Sy

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Organoselenium compounds for cancer chemoprevention does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Organoselenium compounds for cancer chemoprevention, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Organoselenium compounds for cancer chemoprevention will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2744935

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.