Compositions and methods of treating calcium renal stones

Details Compositions and methods of treating calcium renal stones Compositions and methods of treating calcium renal stones

1989-09-27

1990-10-30

Rollins, John W.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Alkali or alkaline earth chloride

424464, 424466, 424468, 514891, A61K 3114, A61K 920, A61K 946, A61K 922

Patent

active

049667769

ABSTRACT:
Methods and compositions useful for the treatment and prophylaxis of calcium renal stones in persons with hypocitraturia or undergoing allopurinol therapy are disclosed. The methods involve administering potassium citrate compositions to persons afflicted with or susceptible to calcium renal stone formations. A typical dosage scheme involves administering about 30 to 120 meq potassium citrate per day in divided doses. Such treatments are effective in dissolving existing calcium stones and preventing formation of new calcium stones. Moreover, the results of a comparative clinical assay indicate the potassium citrate is superior to sodium citrate in the treatment of uric acid lithiasis. Potassium citrate therapy averts calcium renal stone formation, a complication which is often associated with sodium citrate or sodium bicarbonate alkalinization therapy.

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