Spiro antibiotic derivatives

Details Spiro antibiotic derivatives Spiro antibiotic derivatives

2011-08-16

2011-08-16

Skowronek, Karlheinz R (Department: 1613)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S221000

Reexamination Certificate

active

07999115

ABSTRACT:
The invention relates to compounds of formula (I) wherein R1represents H, alkyl, alkoxy, cyano or halogen; one of U and X represents CH or N and the other represents CH, or, in the case of U, may also represent CRaand, in the case of X, may also represent CRb; Rarepresents halogen; Rbrepresents halogen or alkoxy; B represents N, D represents CH2and A represents CH(OH)CH2or CH2CH2, or B represents CH, D represents CH2or O and A represents OCH2, CH2CH(OH), CH(OH)CH2, CH(OH)CH(OH), CH═CH, CH2CH2or NHCO, or also B represents C(OH), D represents CH2and A represents OCH2, CH2CH(OH), CH(OH)CH2, CH(OH)CH(OH), CH═CH, CH2CH2Or NHCO; R2represents H, alkyl, alkenyl, hydroxyalkyl or alkoxycarbonylalkyl; and E represents naphthyl or a binuclear heterocyclic group; and to salts of such compounds. These compounds are useful as antimicrobial agents.

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