3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy}...

Details 3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy}... 3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy}...

2011-08-02

2011-08-02

Andres, Janet (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S316000

Reexamination Certificate

active

07989629

ABSTRACT:
The present invention relates to a compound of formula (I), or a salt thereofwherein the naphthalene ring is substituted in the 2, 3, 4, 5, 6, 7 or 8 position by R1, and R1represents —CH2CH2COOH or —CH═C(CH3)COOH, and to processes for their preparation, to compositions containing them and to their use in the treatment of various inflammatory and/or allergic diseases, such as diseases such as allergic rhinitis.

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Scadding, G. “Predicting and Establishing the Clinical Efficacy of a Histamine H1-Receptor Antagonist” Clinical Drug Investigation Mar. 1, 2005 25(3), 153-164.
Simons, F. “Antihistamines” Middleton's Allergy: Principles and Practice Sixth edition. Chapter 51: 834-863, 2003.
Grant R. Zimmermann “Multi-target therapeutics: when the whole is greater than the sum of the parts.” Drug Discovery Today 2007, 12, 34-42.
Borisy et. al. “Systematic discovery of multicomponent therapeutics” PNAS 2003, 100, 7977-7982.
Sylvain Celanier, Maikel Wijtmans, Patrice Talaga, Rob Leurs, Iwan J. P. De Esch; Histamine H3 receptor Antagonists reach out for the clinic; Drug Discovery Today; Dec. 2005; 10; 1613-1627; Elsevier Science Ltd; London, UK.
McLeod et al.; “Effect of combined histamine H1 and H3 receptor blockade on cutaneous microvascular permeability elicited by compound 48/80”; Life Sciences; 2005; vol. 76, No. 16; pp. 1787-1794; Pergamon Press; Oxford, GB.

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