Synthesising method and benzoxathiepine intermediates

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C549S355000, C560S017000, C560S152000, C562S431000, C562S512000

Reexamination Certificate

active

07902381

ABSTRACT:
The invention relates to preparing derivatives of formula (1), wherein, in particular R1and R2, identical or different, represent a hydrogen, flourine or chlorine atom, a hydroxy group, an alkyl radical and an alkoxy radical, R3is an alkyl radical, a hydroxy group, or a methoxy radical, R4is a hydrogen atom or a methyl radical and R5and R6, identical or different, represent a hydrogen atom, an alkyl radical, an alkoxy radical, an alkylthio radical, and an alkylamino radical. The inventive method consists in reducing an amid of formula (9).

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Mickel, S.J. et al.; Organic Process Research & Development, vol. 8, No. 1, pp. 92-100 (2004).
Huang, P-Q. et al.; Tetrahedon Letters, No. 42, pp. 9039-9041 (2001).
Chen,C. et al.; J. Org. Chem., vol. 68, No. 7, pp. 2633-2638 (2003).

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