Process for preparing 1-polyhaloalkyl-3,4-dihydro-2-(1H)-quinazo

Details Process for preparing 1-polyhaloalkyl-3,4-dihydro-2-(1H)-quinazo Process for preparing 1-polyhaloalkyl-3,4-dihydro-2-(1H)-quinazo

1976-12-27

1977-09-13

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D23982

Patent

active

040481689

ABSTRACT:
3,4-Dihydro-2(1H)-quinazolinone derivatives of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, lower alkylthio or lower alkoxy, or, when taken together, R.sub.1 and R.sub.2 may form methylenedioxy; R.sub.3 is polyhalo-lower alkyl; R.sub.4 is phenyl, halophenyl, lower alkoxyphenyl, lower alkylphenyl or thienyl; and X is oxygen or sulfur, which are known to be very useful intermediates for the preparation of anti-inflammatory and analgesic agents, are obtained in a high yield by reacting a compound of the formula, ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and X are as defined above, with a compound of the formula,

REFERENCES:
patent: 3748331 (1973-07-01), Cooke et al.

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