Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing nitrogen-containing organic compound
Reexamination Certificate
2011-03-29
2011-03-29
Zucker, Paul A (Department: 1621)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing nitrogen-containing organic compound
56
Reexamination Certificate
active
07915019
ABSTRACT:
A process for preparing an optically active (S or R)-β-amino acid represented by formula (II):wherein R represents an alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aralkyl group, aryl group or heteroaryl group each of which may have a substituent(s), and * represents an asymmetric carbon atom,and an optically active (R or S)-β-amino acid ester represented by formula (III):wherein R has the same meaning as defined above, R1represents an alkyl group which may have a substituent(s), and * represents an asymmetric carbon atom, provided that it has a reverse absolute configuration to that of the compound of the formula (II),which comprises selectively hydrolyzing water and one of enantiomers of a β-amino acid ester represented by formula (I):wherein R and R1have the same meanings as defined above,which is a racemic mixture, in the presence of a hydrolase in an organic solvent.
REFERENCES:
patent: 5350572 (1994-09-01), Savaides et al.
patent: 6869781 (2005-03-01), Groger et al.
patent: 2004/0029236 (2004-02-01), Groger et al.
patent: 1456676 (2003-11-01), None
patent: 1361279 (2003-11-01), None
patent: 1367129 (2003-12-01), None
patent: 1621529 (2006-02-01), None
patent: 2003-325195 (2003-11-01), None
patent: 2003-325197 (2003-11-01), None
patent: WO 2004/083163 (2004-09-01), None
Solomons, Organic Chemistry, 5th Edition, 1992, John Wiley & Sons, Inc, New York, pp. 1125-1133.
Secundo et al, Biotechnology and Bioengineering, Optimization of Pseudomonas cepacia Lipase Preparations for Catalysis in Organic Solvents, 1999, 62(5), pp. 554-561.
Chemistry Bulletin, May 31, 1995, entitled New Advances In the Research of Enzyme-Catalyzed Reactions in Organic Solvents—Control and Adjustment of Enzyme's Catalytic Activity and Selectivity (and partial translation).
Chinese Office Action issued Sep. 25, 2009, in CN-200580034133.
Database XP-002548656, Sep. 27, 1994, corresponding to U.S. Patent No. 5,350,572.
Database XP-002548657, Synthesis and Biological Evaluation of S-acyl-3-thiopropyl Prodrugs of N-pjosphonoacetyl-L-aspartate (PALA), Gagnard et al., European Journal of Medicinal Chemistry, 2003, vol. 38, No. 10, pp. 883-891.
European Search Report issued Oct. 14, 2009, in EP 05793727.8.
Faulconbridge SJ. et al., Tetrahedron Letters, (2000), vol. 41, pp. 2679 to 2681.
Gagnard et al., “Synthesis and biological evaluation of S-acyl-3-thiopropyl prodrugs of N-phosphonoacetyl-L-aspartate (PALA)”, European Journal of Medicinal Chemistry, vol. 38, pp. 883-891, (2003).
Office Action mailed May 18, 2010 in Japanese application No. 2006-539349.
Konegawa Tadayoshi
Miyata Hiroyuki
Yamamoto Yasuhito
Birch & Stewart Kolasch & Birch, LLP
Ube Industries Ltd.
Zucker Paul A
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