Bis(ferrocenylphosphino) ferrocene ligands used in...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing

Reexamination Certificate

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C556S014000, C562S496000

Reexamination Certificate

active

07977499

ABSTRACT:
Abstract Compounds of the formula (I) in the form of racemates, enantiomerically pure diastereomers or a mixture of diastereomers, where the radicals R1are identical or different and are each C1-C4-alkyl; m is 0 or an integer from 1 to 4; n is 0 or an integer from 1 to 3; p is 0 or an integer from 1 to 5; R2is an aromatic hydrocarbon radical or a C-bonded heterohydrocarbon radical and R3is an aliphatic or C-bonded heteroaliphatic hydrocarbon radical; R2and R3are identical or different and are each an aliphatic or C-bonded heteroaliphatic hydrocarbon radical; R4is an unsubstituted or C1-C6-alkyl-, C1-C6-alkoxy- or halogen-substituted hydrocarbon radical; and A is a secondary amino group, are ligands for metal complexes which are suitable as catalysts for homogeneous enantioselective hydrogenation.

REFERENCES:
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patent: 01/58588 (2001-08-01), None
patent: 2006/075166 (2006-07-01), None
patent: 2006/075177 (2006-07-01), None
patent: 2007/113155 (2007-10-01), None
International Search Report dated May 21, 2008 in the International (PCT) Application PCT/EP2008/051836 of which the present application is the U.S. National Stage.
PCT Written Opinion dated May 21, 2008 in the International (PCT) Application PCT/EP2008/051836 of which the present application is the U.S. National Stage.
Weiping Chen et al., “Stereoselective Synthesis of Ferrocene-Based C2-Symmetric Diphosphine Ligands: Application to the Highly Enantioselective Hydrogenation of α-Substituted Cinnamic Acids”, Angewandte Chemie, International Edition, vol. 46, No. 22, pp. 4141-4144, XP009100217, ISSN: 1433-7851, May 25, 2007.
Ulrike Nettekoven et al., “Steric and Electronic Ligand Perturbations in Catalysis: Asymmetric Allylic Substitution Reactions Using C2-Symmetrical Phosphorus-Chiral (Bi)ferrocenyl Donors”, Journal of Organic Chemistry, vol. 66, No. 3, pp. 759-770, XP002325578, ISSN: 0022-3263, Oct. 1, 2001.
Jere D. Fellmann et al., Phosphorus- And Arsenic-Bridged [1]Ferrocenophanes. 3. Hydroformylation Catalyzed by the Products of the Interaction of Co2(CO)8, with 1,1′-Ferrocenylenephenylphosphine Oligomers and Polymers, Organometallics, vol. 2, No. 7, pp. 818-825, XP009100216, ISSN: 0276-7333, 1983.
Howard P. Withers et al., “Phosphorus- and Arsenic-Bridged [1]Ferrocenophanes. 2. Synthesis of Poly((1,1′-ferrocenediyl)phenylphosphine) Oligomers and Polymers”, Organometallics, vol. 1, No. 10, pp. 1283-1288, XP009100215, ISSN: 0276-7333, 1982.

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