Multi-spectral whole-slide scanner

Details Multi-spectral whole-slide scanner Multi-spectral whole-slide scanner

2011-01-04

2011-01-04

Grant, II, Jerome (Department: 2625)

Facsimile and static presentation processing

Facsimile

Picture signal generator

C358S484000, C385S115000

Reexamination Certificate

active

07864379

ABSTRACT:
An array microscope scans a slide in rapid sequence at different wavelengths to record multiple spectral images of the sample. Full spatial resolution of the image sensor is realized at each color because pixels are not shared between spectral bands. The object and detector are placed at conjugate distances selected to produce substantially equal magnification with minimum chromatic aberration at all wavelengths to ensure registration of all images. Spectral analysis is carried out by combining the images captured at each wavelength. The greater-than-RGB spectral resolution provided by the combination of images enables the isolation and display of the effects produced by the contemporaneous use of more than two stains on a tissue for improved pathological analysis.

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