RNA interference mediated inhibition of interleukin and...

Details RNA interference mediated inhibition of interleukin and... RNA interference mediated inhibition of interleukin and...

2011-04-12

2011-04-12

McGarry, Sean (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

Reexamination Certificate

active

07923549

ABSTRACT:
This invention relates to compounds, compositions, and methods useful for modulating interleukin and/or interleukin receptor gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of interleukin and/or interleukin receptor gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of interleukin and/or interleukin receptor genes.

REFERENCES:
patent: 5814620 (1998-09-01), Robinson et al.
patent: 5998203 (1999-12-01), Matulic-Adamic et al.
patent: 5998206 (1999-12-01), Cowsert
patent: 7683165 (2010-03-01), McSwiggen et al.
patent: 2003/0083294 (2003-05-01), Sullenger et al.
patent: 2004/0259247 (2004-12-01), Tuschl et al.
patent: 2005/0020521 (2005-01-01), Rana
patent: 2005/0080246 (2005-04-01), Allerson et al.
patent: 2005/0143333 (2005-06-01), Richards et al.
patent: 2359180 (2000-03-01), None
patent: WO-90/14090 (1990-11-01), None
patent: WO-94/01550 (1994-01-01), None
patent: WO-99/32619 (1999-07-01), None
patent: WO-99/49029 (1999-09-01), None
patent: WO-00/44895 (2000-08-01), None
patent: WO-00/44914 (2000-08-01), None
patent: WO-01/36646 (2001-05-01), None
patent: WO-01/96584 (2001-12-01), None
patent: WO-01/96584 (2001-12-01), None
patent: WO-02/22636 (2002-03-01), None
patent: WO-02/44321 (2002-06-01), None
patent: WO-02/44321 (2002-06-01), None
patent: WO-03/064626 (2003-08-01), None
patent: WO-03/064626 (2003-08-01), None
GenBank Accession No. NM—000418, downloaded from http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=4557668, downloaded Sep. 9, 2004.
Callard et al. (Immunology Today, 1996 vol. 17:108-110).
Ikizawa et al. (Clinical Experimental Immunology, 1995 vol. 100:383-389).
Parrish et al. (Molecular Cell, 2000, vol. 6: 1077-1087).
Pieken et al. (Science, 1991, vol. 253: pp. 314-317).
Braasch et al. (Biochemistry 2002, Vo. 41(14): 4503-4510).
Caplen (Expert Opin Biol Ther, Jul. 2003, 3(4), pp. 575-586).
Anderson et al. “Bispecific Short Hairpin siRNA Constructs Targeted to CD4, CXCR4, and CCR5 Confer HIV-1 Resistance,”Oligonucleotides13(5):303-312 (2003).
Elbashir et al. “Analysis of Gene Function in Somatic Mammalian Cells Using Small Interfering RNAs,”Methods26(2):199-213 (2002).
Elbashir et al. “Duplexes of 21-Nucleotide RNAs Mediate RNA Interference in Cultured Mammalian Cells,”Nature411(6836):494-498 (2001).
Elbashir et al. “Functional Anatomy of siRNAs for Mediating Efficient RNAi inDrosophila melanogasterEmbryo Lysate,”EMBO J. 20(23):6877-6888 (2001).
Elbashir et al. “RNA Interference is Mediated by 21- and 22-Nucleotide RNAs,”Genes Dev. 15(2):188-200 (2001).
Fire et al. “Potent and Specific Genetic Interference by Double-Stranded RNA inCaenorhabditis elegans,” Nature391:806-811 (1998).
Futami et al. “Induction of Apoptosis in HeLa Cells with siRNA Expression Vector Targeted Against Bcl-2,”Nucleic Acids Research Supplement2:251-252 (2002).
International Search Report mailed on Mar. 31, 2005 for PCT/US04/16390, 2 pages.
International Search Report mailed on Oct. 17, 2003 for PCT/US03/05028, 2 pages.
International Search Report mailed on Oct. 17, 2003 for PCT/US03/05346, 1 page.
Leirdal et al. “Gene Silencing in Mammalian Cells by Preformed Small RNA Duplexes,”Biochemical and Biophysical Research Communications295:744-748 (2002).
Lin et al. “A Novel mRNA-cDNA Interference Phenomenon for Silencing Bcl-2 Expression in Human LNCaP Cells,”Biochemical and Biophysical Research Communications281:639-644 (2001).
Tuschl et al. “Small Interfering RNAs: A Revolutionary Tool for the Analysis of Gene Function and Gene Therapy,”Molecular Interventions295(3):158-167 (2002).
Tuschl et al. “Targeted mRNA Degradation by Double-Stranded RNA In Vitro,”Genes and Development13(24):3191-3197 (1999).
Office Action mailed on Jul. 1, 2008 for U.S. Appl. No. 11/499,520, 13 pages.
Office Action mailed on Oct. 8, 2008 for U.S. Appl. No. 11/499,529, 34 pages.
Office Action mailed on Nov. 14, 2008 for U.S. Appl. No. 11/502,875, 14 pages.
Office Action mailed on Apr. 8, 2009 for U.S. Appl. No. 11/502,876, 31 pages.
Office Action mailed on Jan. 26, 2009 for U.S. Appl. No. 11/676,124, 15 pages.
Office Action mailed on Feb. 3, 2009 for U.S. Appl. No. 10/693,059, 7 pages.
Office Action mailed on Jul. 2, 2008 for U.S. Appl. No. 10/757,803, 26 pages.
Office Action mailed on Apr. 16, 2009 for U.S. Appl. No. 12/105,010, 24 pages.
Office Action mailed on Feb. 18, 2005 for U.S. Appl. No. 10/444,853, 24 pages.
Office Action mailed on May 17, 2005 for U.S. Appl. No. 10/444,853, 15 pages.
Office Action mailed on Jul. 5, 2005 for U.S. Appl. No. 10/444,853, 19 pages.
Office Action mailed on Jan. 5, 2006 for U.S. Appl. No. 10/444,853, 18 pages.
Office Action mailed on May 3, 2006 for U.S. Appl. No. 10/444,853, 16 pages.
Office Action mailed on Jul. 24, 2006 for U.S. Appl. No. 10/444,853, 18 pages.
Office Action mailed on Oct. 30, 2006 for U.S. Appl. No. 10/444,853, 20 pages.
Office Action mailed on Jun. 4, 2007 for U.S. Appl. No. 10/444,853, 12 pages.
Office Action mailed on Feb. 4, 2008 for U.S. Appl. No. 10/444,853, 37 pages.
Office Action mailed on Nov. 5, 2008 for U.S. Appl. No. 10/444,853, 22 pages.
Office Action mailed on May 7, 2009 for U.S. Appl. No. 10/444,853, 36 pages.
Office Action mailed on Nov. 2, 2006 for U.S. Appl. No. 10/863,973, 20 pages.
Office Action mailed on Oct. 30, 2007 for U.S. Appl. No. 10/863,973, 20 pages.
Office Action mailed on Jan. 4, 2008 for U.S. Appl. No. 10/863,973, 36 pages.
Office Action mailed on Aug. 5, 2008 for U.S. Appl. No. 10/863,973, 29 pages.
Office Action mailed on Feb. 5, 2009 for U.S. Appl. No. 12/203,707, 12 pages.

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