Method of evaluating effect of prolonging QT interval in...

Surgery – Diagnostic testing – Cardiovascular

Reexamination Certificate

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Reexamination Certificate

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08000781

ABSTRACT:
A method for evaluating electrocardiogram QT interval-prolonging action of a test substance, which comprises preparing a hamster anesthetized under such a condition that end of T wave is definitely observed on an electrocardiogram, and comparing electrocardiogram QT intervals of the hamster observed before and after administration of the test substance to evaluate electrocardiogram QT interval-prolonging action of the test substance.

REFERENCES:
patent: 4756904 (1988-07-01), Crook
patent: 2005/0215540 (2005-09-01), Marks et al.
patent: 2005 533086 (2005-11-01), None
Matsumoto, Yasunori et al., “Long-Term Endothelin A Receptor Blockade Inhibits Electrical Remodeling in Cardiomyopathic Hamsters”, Circulation, vol. 106, pp. 613-619, (2002).
H. Katoh, el al. “Comparison of QT Interval in Several Experimental Animals and the Effects of E4031, Class I I I Antiarrhythmic Agent”, The Journal of Toxicological Sciences, Proceedings of the 25thAnnual Meeting, vol. 23, No. 4, 1998, p. 344 (P6-2).
Ivan Kocic, et al. “Regional and Frequency-Dependent Changes in Action Potentials and Transient Outward K+ Currents in Ventricular Myocytes from J-2-K Cardiomyopathic Hamsters”, Basic Research in Cardiology, vol. 98, No. 6, 2003, pp. 367-379.
Nobuya Matsuoka, et al. “Characterzation of Stress-Induced Sudden Death in Cardiomyopathic Hamsters”, The Journal of Pharmacology and Experimental Therapeutics, vol. 284, No. 1, 1998, pp. 125-135.
Atsushi Takeda et al, “Three-Dimensional Distribution of Myocardial Fibrosis in the New J-2-N Cardiomyopathic Hamster: Comparison with Electrocardiographic Findings”, Heart and Vessels, vol. 8, No. 4, 1993, pp. 186-193.
Takashi Kawashima, et al. “ECG Analysis of Golden Hamsters Exposed to Long Term-GZ Conditions: Ordinary and Pathological Findings” The Japanese Journal of Physiology, vol. 41, No. 4, 1991, pp. 629-651.
Osamu Hano, et al. “Arrhythmogenic Properties of the Ventricular Myocardium in Cardiomyopathic Syrian Hamster, BIO 14.6 Strain”, Cardiovascular Research, vol. 25, 1991, pp. 49-57.
Hiroshi Tone, et al. “Effect of (2″R)-4′-0-Tetrahydropyranyladriamycin, A New Antitumor Antibiotic, On the Cardiac Function of Hamsters”, The Japanese Journal of Antibiotics, vol. 39, Feb. 1986, pp. 547-568 (with an English Abstract thereof on the last page).
Tatsuo Hoshino et al, Electrocardiographic Abnormalities in Syrian Golden Hamsters with Coxsackievirus B, Myocarditis, Japanese Circulation Journal, vol. 46, Dec. 1982, pp. 1305-1312.

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