Increasing hybridization efficiencies

Details Increasing hybridization efficiencies Increasing hybridization efficiencies

2011-04-05

2011-04-05

Kapushoc, Stephen (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091300, C435S091510, C435S287200, C536S023100, C536S024300

Reexamination Certificate

active

07919239

ABSTRACT:
Aspects of the disclosure are generally directed to probes and probe compositions for detecting or quantifying a target. One aspect provides a method for selectively hybridizing a probe to a polynucleotide by contacting a sample containing a first and second polynucleotide with a probe. The probe includes a number of nucleotides complementary to the first or second polynucleotide in the region of mismatch between the first and second polynucleotides. Another aspect provides arrays including the disclosed probes and methods of using the arrays and the probes.

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