Triazolopyridine carboxamide derivatives and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S253040, C514S300000, C544S254000, C544S362000, C546S117000

Reexamination Certificate

active

07863279

ABSTRACT:
The invention relates to the triazolopyridine carboxamide derivatives and triazolopyrimidine carboxamide derivatives of general formula (I):Wherein X, A, R1and R2are as defined herein. The invention further relates to preparation methods and therapeutic use thereof.

REFERENCES:
patent: 2009/0030011 (2009-01-01), Petry et al.
patent: WO 02/055083 (2002-07-01), None
patent: WO 2004/035550 (2004-04-01), None
patent: WO 2005/073199 (2005-08-01), None
patent: WO 2006/138657 (2006-12-01), None
patent: WO 2007/045392 (2007-04-01), None
Fox et al. Expert Opin.Investig.Drugs, vol. 14, p. 695-703 (2005).
Teare et al.Expert Opin.Investig.Drugs, vol. 14, p. 859-869 (2005).
Cravatt et al. Current Opinion in Chemical Biology, vol. 7, p. 469-475 (2003).
Magrioti et al. Bioorganic & Medicinal Chemistry Letters, vol. 18, p. 5424-5427 (2008).
Parker et al. Physiology & Behavior, vol. 97, p. 121-124 (2009).
Dinh, T. P., et. al., Brain Monoglyceride Lipase Participating in Endocannabinoid Inactivation, PNAS, (2002), vol. 99, No. 16, pp. 10819-10824.
Dinh, T. P., et al., RNA interference Suggests a Primary Role for Monoacylglycerol Lipase in the Degradation of the Endocannabinoid 2-Arachidonoylglycerol, Molecular Pharmacology, (2004), vol. 66, No. 5, pp. 1260-1264.
Fowler, C. J., et. al., Ibuprofen Inhibits Rat Brain Deamidation of Anandamide at Phamacologically Relevant Concentrations. Mode of Inhibition and Structure-Activity Relationship, The Journal of Pharmacology and Experimental Therapeutics, vol. 283, No. 2, pp. 729-734, (1997).
Karlsson, M., et. al., cDNA Cloning, Tissue Distribution, and Identification of the Catalytic Triad of Monoglyceride Lipase, The Journal of Biological Chemistry, vol. 272, No. 43, pp. 27218-27223, (1997).
Kondo, S., et. al., 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Agonist: Identification as One of the Major Species of Monoacylglycerols in Various Rat Tissues, and Evidence for its Generation Through Ca2+-Dependent and -Independent Mechanisms, FEBS Letters, vol. 429, (1998), pp. 152-156.
Omeir, R. L., et. al., Arachidonoyl Ethanolamide-[1,2-14c] as a Substrate for Anandamide Amidase, Life Sciences, vol. 56, No. 23/24, pp. 1999-2005, (1995).
Saario, S. M., et. al., Monoglyceride Lipase-Like Enzymatic Activity is Responsible for Hydrolysis of 2-Arachidonoylglycerol in Rat Cerebellar Membranes,Biochemical Pharmacology, vol. 67, (2004), pp. 1381-1387.
Savinainen, J. R. . et. al. , Despite Substantial Degradtion, 2-Arachidonoylglycerol is a Potent Full Efficacy Agonist Mediating CB1 Receptor-Dependent G-Protein Activation in Rat Cerebellar Membranes, British Journal of Pharmacology, (2001), vol. 134, pp. 664-672.
Suguira, T., et. al., Biochemistry, Pharmacology and Physiology of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand , Progress in Lipid Research, vol. 45, (2006) pp. 405-446.
Sugiura, T., et. al., Evidence That 2-Arachidonoylglycerol but Not N-Palmitoylethanolamine or Anandamide is the Physiological Ligand for the Cannabinoid CB2 Receptor, The Journal of Biological Chemistry, vol. 275, No. 1, pp. 605-612, (2000).
Sugiura, T., et. al., Evidence That the Cannabinoid CB1 Receptor is a 2-Arachidonoylglycerol Receptor, The Journal of Biological Chemistry, vol. 274, No. 5, pp. 2794-2801, (1999).
Ueda, N., et. al.,, The Fatty Acid Amide Hydrolase (FAAH), Chemistry and Physics of Lipids, vol. 108, (2000), pp. 107-121.
Rice, K. D., et al., Dibasic Inhibitors of Human Mast Cell Tryptase. Part 1: Synthesis and Optimization of a Novel Class of Inhibitors, Bioorganic & Medicinal Chemistry Letters, vol. 10, (2000), pp. 2357-2360.
Vaughn, J. R., et al., Triazolo and Imidiazopyridines, J. Am. Chem. Soc., (1949), pp. 1885-1887.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Triazolopyridine carboxamide derivatives and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Triazolopyridine carboxamide derivatives and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Triazolopyridine carboxamide derivatives and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2716132

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.