Antibodies against vascular endothelial growth factor...

Details Antibodies against vascular endothelial growth factor... Antibodies against vascular endothelial growth factor...

2011-07-05

2011-07-05

Huynh, Phuong (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S141100, C424S143100, C530S387100, C530S388150, C530S388220

Reexamination Certificate

active

07972596

ABSTRACT:
Monoclonal antibodies that are specific for vascular endothelial growth factor receptor 1 (VEGFR-I). This invention also provides nucleotide sequences encoding and amino acid sequences comprising variable heavy and light chain immunoglobulin molecules, including sequences corresponding to the complementarity determining regions of CDR1, CDR2, and CDR3. The invention also provides methods for generation and expression of anti -VEGFR-I antibodies and methods of treating angiogenic-related disorders and reducing tumor growth by administering anti-VEGFR-I antibodies.

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