Nitric oxide donors and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S202000

Reexamination Certificate

active

07968575

ABSTRACT:
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.

REFERENCES:
patent: 4505857 (1985-03-01), Egli
patent: 4923886 (1990-05-01), Shiokawa et al.
patent: 5404871 (1995-04-01), Goodman et al.
patent: 5542410 (1996-08-01), Goodman et al.
patent: 5807847 (1998-09-01), Thatcher et al.
patent: 5874063 (1999-02-01), Briggner et al.
patent: 5883122 (1999-03-01), Thatcher et al.
patent: 5983956 (1999-11-01), Trofast
patent: 6221398 (2001-04-01), Jakupovic et al.
patent: 6268533 (2001-07-01), Gao et al.
patent: 6310052 (2001-10-01), Thatcher et al.
patent: 6488951 (2002-12-01), Toone et al.
patent: 6552047 (2003-04-01), Garvey et al.
patent: 6566324 (2003-05-01), Nadel et al.
patent: 6571790 (2003-06-01), Weinstein
patent: 6637430 (2003-10-01), Voges et al.
patent: 6652323 (2003-11-01), Yanda
patent: 6916835 (2005-07-01), Thatcher et al.
patent: 7189750 (2007-03-01), Assaf et al.
patent: 7368577 (2008-05-01), Assaf et al.
patent: 2002/0177622 (2002-11-01), Thatcher et al.
patent: 2005/0137191 (2005-06-01), Thatcher et al.
patent: 2008/0233163 (2008-09-01), Assaf
patent: 0452782 (1991-10-01), None
patent: WO 99/55319 (1999-04-01), None
patent: WO 00/30614 (2000-02-01), None
patent: WO 01/49275 (2001-07-01), None
patent: WO 03/086282 (2003-10-01), None
patent: WO2005/105065 (2005-11-01), None
Silberg et al., caplus an 1965:88847.
Schonafinger, Heterocyclic NO prodrugs, II Farmaco, 54 (1999), 316-320.
Munzel, JACC, 2001, 38, 1102-1105.
Thatcher et al, caplus an 2005:547257.
U.S. Appl. No. 09/473,713, filed Dec. 29, 1999, Thatcher et al.
Kumar et al. “Design, Synthesis, and Evaluation of α-Ketoheterocycles as Class C β-Lactamase Inhibitors”, Bioorganic & Medicinal Chemistry, 9: 2035-2044, 2001.
Cavicchi et al. “Inhibition of Inducible Nitric Oxide Synthase in the Human Intestinal Epithelial Cell Line, DLD-1, by the Inducers of Heme Oxygenase 1, Bismuth Salts, Heme, and Nitric Oxide Donors”, GUT, 47(6): 771-778, 2000. Abstract.
Salas et al. “Nitric Oxide Supplementation Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice”, Laboratory Investigation, 82(5): 597-607, 2002. Abstract, p. 602, col. 1, Lines 3-19.
Ueda et al. “Structure-Activity Relationships of 2-Aminothiazole Derivatives as Inducible Nitric Oxide Synthase Inhibitor”, Chemical & Pharmaceutical Bulletin, 52(5): 634-637, 2004. Abstract, p. 634, col. 2, Last Line—p. 635, col. 1, Line 2, Table 2, Expls. 5a, 5b, 7, p. 636, col. 1, Lines 17-18, 25-39.
Münzel et al. “Evidence fpr Enhanced Vascular Superpxide Anion Production”, The Journal of Clinical Investigation, 95: 187-194, 1995.
Chung et al. Identification of the Subcellular Site for Nitroglycerin Metabolism to Nitric Oxide in Bovine Coronary Smoth Muscle Cells, The Journal of Pharmacology and Experimental Therapeutics, 253(2): 614-619, 1990.
McGuire et al. “Inhibition of NADPH-Cytochrome P450 Reductase and Glyceryl Trinitrate Biotransformation by Diphenyleneidononium Sulfate”, Biochemical Pharmacology, 56: 881-893, 1998.
Needleman et al. “Sulfhydryl Requirement for Relaxation of Vascular Smooth Muscle”, The Journal of Pharmacology and Experimental Therapeutics, 187(2): 324-331, 1973.
Bueb et al. “Natural Polyamines Stimulate G-Proteins”, Biochemical Journal, 282: 545-550, 1992.
Loscalzo “N-Acetylcysteine Potentiates Inhibition of Platelet Aggregation by Nitroglycerin”, Journal of Clinical Investigation, 76: 703-708, 1985.
Kurz et al. “Nitroglycerin Metabolism in Vascular Tissue: Role of Glutathione S-Transferases and Relationship Between NO and NO2-Formation”, Biochemical Journal, 292: 545-550, 1993.
Official Action Dated Jan. 4, 2007 From the US Patent Office Re.: U.S. Appl. No. 11/266,346.
Official Action Dated Oct. 12, 2007 From the US Patent Office Re.: U.S. Appl. No. 11/266,346.
Official Action Dated Oct. 17, 2008 From the US Patent Office Re.: U.S. Appl. No. 11/266,346.
International Search Report Dated Aug. 16, 2005 From the International Searching of the Patent Cooperation Treaty Authority Re.: Application No. PCT/IL2005/000481.
Official Action Dated Jul. 31, 2007 From the US Patent and Trademark Office U.S. Appl. No. 11/266,464.
International Preliminary Report on Patentability Dated Apr. 20, 2006 From the International Preliminary Examining Authority Re.: Application No. PCT/IL2005/000481.
Official Action Dated Apr. 3, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/266,431.
Official Action Dated Apr. 4, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/266,346.
Official Action Dated Jan. 14, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/266,346.
Official Action Dated Oct. 17, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/266,346.
Official Action Dated Sep. 26, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/266,431.
Official Action Dated Apr. 28, 2006 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/266,441.
Official Action Dated May 30, 2006 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/266,443.
Official Action Dated Sep. 29, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 12/076,828.
International Search Report Dated Nov. 2, 2005 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL2005/000480.
Notice of Allowance Dated Oct. 10, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/266,424.
Official Action Dated Jun. 11, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/266,424.
Official Action Dated May 16, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/266,424.
Written Opinion Dated Nov. 2, 2005 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL2005/000480.
Written Opinion Dated Aug. 16, 2005 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL2005/000481.
Cavicchi et al. “Inhibition of Inducible Nitric Oxide Synthase in the Human Intestinal Epithelial Cell Line, DLD-1, by the Inducers of Heme Oxygenase 1, Bismuth Salts, Heme, and Nitric Oxide Donors”, GUT, 47(6): 771-778, 2000. Abstract.
Golub et al. “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring”, Science, 286: 531-537, 1999.
Golub et al. “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring”, Science, 286: 531-537, 1999.

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