System and method of using vagal stimulation to assess...

Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical therapeutic systems

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07869870

ABSTRACT:
A method and apparatus for using vagal stimulation to detect autonomic tone and assess a patient's risk of sudden cardiac death (SCD) are presented. The method involves stimulating the patient's vagus nerve in order to induce a drop in arterial blood pressure, which simulates the patient's cardiovascular response to a premature ventricular contraction (PVC). Sinus rhythm data just before and immediately following the stimulation is recorded and analyzed for a degree of heart rate turbulence (HRT) in order to detect abnormalities in autonomic tone and assess the risk of SCD. In an embodiment, the method is implemented in an implantable cardiac device (ICD), which can deliver arrhythmia prevention therapy based on the risk of SCD. The method can assess the patient's vagal activity on-demand by measuring HRT without relying on naturally occurring PVCs and eliminates the risk of causing arrhythmia associated with artificially inducing PVCs in order to measure HRT.

REFERENCES:
patent: 5330507 (1994-07-01), Schwartz
patent: 6922585 (2005-07-01), Zhou et al.
patent: 7079887 (2006-07-01), Burnes et al.
patent: 7225017 (2007-05-01), Shelchuk
patent: 2003/0191403 (2003-10-01), Zhou et al.
patent: WO 03/086187 (2003-10-01), None
Schmidt G et al., Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction, The Lancet, Apr. 24, 1999, vol. 353, 1390-1396.
Malik, et al., “Heart-rate Turbulence”, G Ital Cardiol, vol. 29, Suppl 5, 1999, 5 pages.
Mrowka, et al., “Blunted Arterial Baroreflex Causes “Pathological” Heart Rate Turbulence”, Am J Physiol Regulatory Integrative Comp Physiol 279: R117-R1175, 2000.
Schmidt, et al., “Heart-rate Turbulence After Ventricular Premature Beats as a Predictor of Mortality After Acute Myocardial Infarction”, The Lancet, vol. 353, Apr. 24, 1999, pp. 1390-1396.
Berkowitsch, et al., “Prognostic Significance of Heart-rate Turbulence in ICD Patients with DCM”, The XIIth World Congress on Cardiac Pacing & Electrophysiology, Hong Kong, Feb. 19-22, 2003, pp. 299-303.
Cygankiewicz, et al., “Heart Rate Turbulence Predicts Cardiac Death in Patients Undergoing CABG Surgery”, Abstract ID: 102431, Publishing ID: 396, 1 page.
Bauer, et al., “Dynamics of Heart Rate Turbulence Predicts Mortality After Acute Myocardial Infarction”, 1 page.
Wichterle, et al., “Turbulence Slope after Atrial Premature Complexes is Significant Mortality Predictor in Patients after Myocardial Infarction”, Abstract: 814-4, Citation: Supplement to Journal of the American College of Cardiology, Mar. 19, 2003, vol. 41, Issue 6, Suppl. A, 2 pages.
Lindgren, et al., “Heart Rate Turbulence after Ventricular and Atrial Premature Beats in Subjects without Structural Heart Disease”, Abstract, Journal of Cardiovascular Electrophysiology, vol. 14, Issue 5, p. 447, May 2003.
“Heart Rate Turbulence Calculation”, Technische Universitat Munchen, 2 pages.
“Heart Rate Turbulence HRT!View” Technische Universitat Munchen, 2 pages.
Jeron, et al., “Association of the Heart Rate Turbulence with Classic Risk Stratification Parameters in Postmyocardial Infarction Patients”, A.N.E., Oct. 2003, vol. 8, No. 4, pp. 296-301.
Davies, et al., “Relation of Heart Rate and Blood Pressure Turbulence Following Premature Ventricular Complexes to Baroreflex Sensitivity in Chronic Congestive Heart Failure”, The American Journal of Cardiology, vol. 87, Mar. 15, 2001, pp. 737-742.
Lin, et al., “Tight Mechanism Correlation Between Heart Rate Turbulence and Baroreflex Sensitivity: Sequential Autonomic Blockage Analysis”, Journal of Cardiovascular Electrophysiology, vol. 13, No. 5, May 2002, pp. 427-431.
Wichterle, et al., “Mechanisms Involved in Heart Rate Turbulence”, Cardiac Electrophysiology Review 2002, vol. 6, No. 3, pp. 262-266.
Watanabe, et al., “Effects of Ventricular Premature Stimulus Coupling Interval on Blood Pressure and Heart Rate Turbulence”, Circulation, Jul. 16, 2002, pp. 325-330.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

System and method of using vagal stimulation to assess... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with System and method of using vagal stimulation to assess..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System and method of using vagal stimulation to assess... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2701065

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.