Nucleic acid encoding proteins involved in protein...

Details Nucleic acid encoding proteins involved in protein... Nucleic acid encoding proteins involved in protein...

2011-04-19

2011-04-19

Carlson, Karen Cochrane (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C536S023100, C435S320100, C530S350000

Reexamination Certificate

active

07927832

ABSTRACT:
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.

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GenBank Accession No. AA258606-zr60c05.s Soares—NhHMPu—S1Homo sapienscDNA clone Image:667784 3' similar to TR:G297035 G297035 SIAH-1A Protein; mRNA sequence.
GenBank Accession No. AA923663-0h08e09.s1 NCI—CGAP—Co8Homo sapienscDNA clone Image: 1457224 3' similar to TR:Q92880 Q92880 Seven in Absentia Homolog; mRNA sequence.
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GenBank Accession No. AL031178-Human DNA sequence from clone 341E18 on chromosome 6p11.2-12.3. Contains a Serine/Threonine Protein Kinase gene (presumptive isolog of a Rat gene) and a novel alternatively spliced gene. Contains a putative CpG island, ESTs and GSSs, complete sequence.

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