Fatty acids analogous

Details Fatty acids analogous Fatty acids analogous

2011-03-08

2011-03-08

Puttlitz, Karl J (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C514S558000

Reexamination Certificate

active

07902399

ABSTRACT:
The present invention relates to novel fatty acid analogous of the general formula (I): R1—[xi—CH2]n—COOR2wherein R1is: a C6-C24alkene with one or more double bonds and/or with one or more triple bonds, and/or a C6-C24alkyne, and/or a C6-C24alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1-C4alkoxy, C1-C4alkylthio, C2-C5acyloxy or C1-C4alkyl, and wherein R2 represents hydrogen or C1-C4alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein Xiindependent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xiis not CH2, and with the proviso that if R1 is an alkye, then the carbon-carbon triple bond is positioned between the (ω-1) carbon and the (ω-2) carbon, or between the (ω-2) carbon and the (ω-3) carbon, or between the (ω-3) carbon and the (ω-4) carbon, a salt, prodrug or complex thereof, which can be used for the treatment and/or prevention of syndrome X, obesity, hypertension, fatty liver, diabetes, hyperglycaemia, hyperinsulinemia and stenosis. Further, the invention relates to a nutritional composition comprising said fatty acid analogues, and a method for reducing the total weight, or the amount of adipose tissue in an animal.

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